The Coordination Chemistry Studies Of Chitosan And Its Carboxymethyl Products

Complex of chitosan-copper(II) was synthesized, the influence of deacetylation degree and temperature to the mass fractions of copper in product were checked, the best conditions for synthesis of copper complexes chitosan were Deacetylation degree of 95%, temperature of 60°C, and quality percentage of copper was 11.24%.Release -controlled capability of product in simulated seawater and its antimicrobial effects to Escherichia coli was studied, the cumulated release rate of product in simulated seawater was just 0.76% 15 days later, which indicated the excellent release -controlled capability of the product. The antimicrobial rate reached 54.5% six days later.Carboxymethyl Chitosan(CMCS) was synthesized under conditions of basification and heat by chitosan and monochloroacetic acid. The product was analyzed by IR, and its apparent viscosity under certain conditions was determined, the apparent viscosity of CMCS rised while concentration increased or temperature declined, thicker solution was affected great when the temperature changed, CMCS's apparent viscosity declined gently with addition of NaCl.CMCS-GA gel based on CMCS was synthesized by cross-linking with glutaraldehyde, which was analyzed by IR. Swelling ratio of CMCS-GA gel in water solution of different pH and swelling ratio of CMCS-GA gel in distilled water at different temperature was determined, the results indicated that Swelling ratio of CMCS-GA gel got to its maximum point at about ph7; Swelling ratio rised with increased alkalescence under alkaline conditions, and declined with increased acidity under acid conditions, the gel dissolved while acidity was too strong; Swelling ratio firstly rised and then declined while temperature changed from 25℃to55℃, and got to the maximum swelling degree point 13.57 at about 40℃.To evaluate the adsorption capability of CMCS-GA gel to aspirin and its application in drug release-controlled system. Aspirin entrapped hydrogel was synthesized by adsorption effect of CMCS-GA gel to aspirin. The swelling characteristics and the release behaviors of aspirin entrapped hydrogel in simulated intestinal juice (pH7.4) have been studied respectively. CMCS-GA in simulated intestinal juice (pH7.4) got to the maximum swelling degree 1.38 in 2h. The adsorbing capacity of aspirin by CMCS-GA was 4.6mg/g, the cumulated release rate of aspirin entrapped hydrogel in simulated intestinal juice (pH7.4) for 96h was 99.91%, which indicated the excellent release-controlled capability of aspirin entrapped hydrogel. The results also showed that the release profile of aspirin from hydrogel followed first order kinetic equations.The complexes of Carboxymethyl Chitosan with copper(II), cadmium (II) and glutaraldehyde have been synthesized, the structures of which were characterized by IR spectra, the mass fractions of copper in product was also checked. Release- controlled capability of product in simulated seawater and seawater was studied respectively, the cumulated release rate of product in simulated seawater was just 0.2390% 32 days later, and the cumulated release rate of product in seawater was just 0.2112% 30 days later, both of them released steadily, which indicated the excellent release-controlled capability of the product.The complexes of Carboxymethyl Chitosan with magnesium(II), calcium(II), zinc(II), iron(II), aluminum(III), cerium(II) have been synthesized, the structures of which were characterized by IR spectra. The free radical scavenging effects of complexes CMCS-Zn(Ⅱ) , CMCS-Ca(Ⅱ) , CMCS-Ce(Ⅱ) on superoxide anion radical by NADH-PMS-NBT system were studied. The results demonstrated that three kinds of the complexes all showed excellent ability for scavenging the superoxide anion radical, and the results also showed positive correlation in scavenging ability and concentration of samples. When mass concentration of samples was 0.004g/l～0.2g/l, complex of Carboxymethyl Chitosan with zinc( II)displayed the highest scavenging effects on the superoxide anion radical, while complex of Carboxymethyl Chitosan with Ca (II) was the next and Carboxymethyl Chitosan with Ce (II)was the lowest .It was deduced that the metal ion had something to do with its ability to scavenging superoxide anion radical.