The Research Of Haemorrhagic Fever With Renal Syndrome Bivalent Purified Vaccine, Inactivated (Vero Cell)

The epidemic hemorrhagic fever(EHF) is caused by Hantaan virus,it is an acute infectious disease(AID).The clinical course of this disease is complex and dangerous ,case fatality rate is high, it is a contagious disease which couse serious harm to our people.After experiment,this dissertation setteled inoculum size of cell,viral infection size, and the production artwork of Haemorrhagic Fever with Renal Syndrome Bivalent Purified Vaccine, Inactivated (Vero Cell)And optimize the artwork of Haemorrhagic Fever with Renal Syndrome Bivalent Purified Vaccine, Inactivated (Vero Cell). This dissertation elevate the puantity of virus in the stook solution by optimize the artwork.Accordingly,boost the preparation output,cut down the production cost.The concentration and chromatography is the most committed step of vaccine dipurant,our focus is to boost the hetero-protein removal ration,specialy to remove BSA,elevate the recovery of viral antigen.And establish a consummate artwork of Haemorrhagic Fever with Renal Syndrome Bivalent Purified Vaccine, Inactivated (Vero Cell)...