Study Of The Inhibition To Tumor Cell Activity With Two Polyoxometalates Containing Molybdenum And Tungsten

Polyoxometalates(POMs) have recently been attracting extensive interest in solid state materials chemistry due to their fascinating properties and great potential applications in many fields such as catalysis, material science, medicine, and magnetochemistry. Polyoxometalates(POMs) as one kind of significant metal oxide clusters with nanosizes and abundant topologies have recently been employed as inorganic building blocks for the construction of new materials. In particular, the chemistry of coordination compounds of polyoxometalates with organic ligands provides knowledge about the interaction of small organic molecules with polyoxometalates surface.In this paper, we used the L ligand and octamolybdate as structural building blocks, reaction of 3-(2-pyridyl)pyrazol with (NH4)2Mo4O13·2H2O and NiCl2·6H2O afforded the complex: [Ni(C8N3H7)3]4[Mo8O26]2·7H2O(1), crystal structure was characterized by using X-ray single–crystal diffraction. Compound(1) is with a novel three-dimensional supramolecular structure. This is hitherto the example observed that the L ligand was used to construct a three-dimensional honeycomb'host'supramolecular network with one-dimensional channels,in whichα- andβ-octamolybdate anions'guest'reside. The tumor growth inhibition activity of some compounds including [Ni(C8N3H7)3]4[Mo8O26]2·7H2O on breast,ovary and lung cancer were measured by cell culturing and interfering in vitro.