Research On The Key Synthetic Intermediate Of Podophyllotoxin

In the first part of the system outlined in the following:Podophyllotoxin and its derivatives possess antitumour activity and some of them, such as Etoposide (VP-16) and Teniposide (VM-26), have been used as anticancer drugs for clinical chemotherapy. The C-4 configuration, which is of crucial importance for biological activity. Otherwise ,the challenge of a stereoselective synthesis is embedded in the formation of the four contiguous stereocenters and the presence of a base sensitive translactone moiety. There are some approaches known from previous literature for synthesis:Diels-Alder reaction, Tandem conjugate addition reaction etal.Papers in the experimental part of our literature considered on the basis of the experimental exploration, and podophyllotoxin intermediates with the structural characteristics of a simple pepper aldehyde as the starting material, a,β-unsaturated carbonyl compounds are selective reduction lithium aluminum hydrogen reduction reaction as the key steps to have the Knoevenagel condensation, peracetic acid epoxy between chlorine and alkaline hydrogen peroxide epoxy, DCC condensation esterification reaction of the podophyllotoxin intermediates.