Synthesis, Crystal Structure And Antibacteria Activity Of A Series Of Ligands And Complexes Of Pyrazole And Triazole

A considerable interest has been focused on a series of derivatives and metal complexes of pyrazole and triazole because of their broad bio-activities, special electromagnetic and coordination properties being used in their potential application.In order to investigate the relationship between the structure and property of pyrazole,triazole and their complexes,twelve complexes had been synthesized by hydratethermal synthesis,including two ligand crystals and ten complex crystals.Their crystal structures,spectrum characters had been characterized,some with antibacterial activities.The complexes {[Cu(pyra)₂(H₂O)]·3H₂O}_n(1)and {[Cu₂(pyra)₂(2,2'-bipy) (4,4'-bipy)₂]·6H₂O}_n(2)have been obtained by taking pyra as a starting material. In the complexe(1),Cu(â…¡)adopts five-coordinated distorted pyramid geometry. In the complexe(2)Cu(â…¡)adopts five-coordinated distorted pyramid.Three similar mononuclear complexes[Cu(tria)₂(H₂O)₂]_n(3),[Zn(tria)₂ (H₂O)2]_n(4)and[Cd(tria)₂(H₂O)₂]_n(5)have been synthesized by the reaction between Tria and metal salts,with Cu(â…¡),Zn(â…¡)and Cd(â…¡)adopt six-coordinated distorted octahedron geometry.After adding to the second ligand,we obtained two similar complexes {[Cu(tria)(phen)Cl]₂}_n(6)and [Cu(tria)(phen)NO₃]_n(7)with Zn(â…¡)in the center of the distorted pyramid geometry.We did the test of antibacterial activity of the five complexes and made the conclusion by compared to MIC.The test result indicate that the complex(6)show good activity and complex(3)and(5)shows no activity.Two three-dimensional Pb polymers(8)and(9)have been prepared by using Pb salt and Tria,with Tria considered as quadridentate ligand.In the complex(8), Cl acted as aμ₂-Cl bridging ligand links two Pb ions and Pb is eight coordinated.In the complex(9),SCN^- acted as aμ₂-N briding ligand links two Pb ions and Pb is seven coordinated.We cultivate a ligand crystal Triam by using methyl 1,2,4-triazole-3-carboxylate as the starting material.Then the one-dimensional Z configuration chain polymer(10)is obtained by using Cu salt,Triam and phen with Triam as the trident-bridging ligand.Complexes was assembled with H-bonds to three-dimensional network so as to form a lot of tunnel cavities which filled with hydrates and nitrates.We cultivate a ligand crystal Triaah by using the starting substance methyl 1,2,4-triazole-3-carboxylate.Every cell contain a unit of four independent hydrazones molecules and a hydrate.Complexes are linked with H-bonds andÏ€-Ï€interactions to form a three-mensional network.