Br(?)nsted Acid-Catalyzed One-Pot Four-Component Synthesis Of 1,2,3,7,8,8a-Hexahydro-5,7,8a-triarylimidazo[1, 2-α] Pyridine Derivatives

Part 1.The Research Progress on Multi-Component Reactions.In recent years,multi-component reactions(MCRs),which response to the rapid development of an efficient synthetic method and green chemistry,have gradually become one of the development trends of synthetic organic chemistry.MCRs,which can be realized by the nucleophilic addition to imines,isocyanid participation,cycloaddition and metal reagents participation and so on,were given the summary of recent in this part.Part 2.Studies of Bronsted Acid-Catalyzed One-Pot Four-Component Synthesis of 1,2,3,7,8,Sa-Hexahydro-5,7,Sa-triarylimidazo[1,2-a]pyridine Derivatives.A simple and effective method for the.synthesis of 1,2,3,7,8,5a-hexahydro-5,7,8a-triarylimidazo[1,2-a]pyridine derivatives catalysted by organic phosphoric acid has been developed utilizing the MCRs technique,which involved the reaction of benzaldehyde, acetophenone and ethane-1,2-diamine.All of the compounds synthesized were characterized by ¹H NMR,¹³C NMR,HRMS,IR spectra and X-Ray.The reaction mechanism was discussed.Part 3.Synthesis and Anti-tumor Activities of 7H-1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazine and 2,4-Disubstituent Thiazole Derivatives Containing Ferrocene.Ten novel 3,6-disubsituted-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine and four 2,4-disubstituted thiazole derivatives containing ferrocene were prepared by the condensation ofα-bromoacetylferrocene with 4-amino-5-substituted-3-thiol-1,2,4-triazoles and thioamide,respectively.The structures of the compounds synthesized were characterized by elemental analyses,IR,¹H NMR and ¹³C NMR spectra.The primary anti-tumor activities were evaluate.