| Sodium alginate is one kind of natural linear polysaccharide which obtains from the brown alga.As a natural polymer material,alginate has a good biocompatibility, abundant raw materials, accessible and inexpensive and widely used in tissue engineering and drug release, and other fields.The paper take the sea alginate acid sodium as a raw material, the thesis mainly includes the following parts:Alginate was hydrophobically modified through polycaprolactone or polylactic acid, The modified alginate was made into hydrophobic modified hydrogel in aqueous solution of sodium chloride and calcium chloride. The hydrogel were used to load Buloh phenol. The in vitro controlled release was investigated.It was usually considered that alginate gels used in tissue engineering degradate very slowly and the degradation products molecular are very great,so it is not easy to discharge from vitro,therefore, its application receives certain limit, based on oxidized alginate and take the calcium chloride as the crosslinking agent,the preparation of calcium ion crossing linking oxidized alginate hydrogels maintains both mechanical properties and the good degeneration performance. The results showed that hydrophobic modified to reduce the sodium alginate hydrophilic, the gel microspheres for drug ibuprofen load increase, with the release of better.Use the same method of preparation of a sodium alginate and polylactic acid Hydrophobic modified gel, on a variety of factors on the hydrogel release of drugs, the swelling gel and water dynamics, the method is mild, can be large Preparation of the scale, the whole process of non-toxic pollution-free, the product can be entirely appropriate under the condition of degradation, saving a lot of energy, in line with the principle of sustainable development, it is worth promoting. The next step for a more reasonable use of sodium alginate gel in tissue engineering, drug delivery systems in areas such as a very good prospect.
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