Diastereoselective Reaction Induced By Natural Camphor And Camphorsultam

In this paper,we had focused on the study on the diastereoselective reaction of camphor and camphorsultam.We researched the asymmetric electronation reaction of natural camphor with Grignard. When natural camphor reacted to Grignard reagent with active hydrogen in theβ-carbon,the carbonyl group of camphor was stereoselectively attacked by Grignard reagent and the reduction process was happened.The effects of reaction time ,reaction tepperature ,the molar on electronation reaction was discussed ,ande the optical reaction condition was obtained.Secondly ,we researched the asymmetric additive reaction of natural camphor with Grignard.When natural camphor reacted to Grignard reagent without active hydrogen in theβ-carbon,the carbonyl group of camphor was stereoselectively attacked by Grignard and the addictive products was obtained.The structure of the product was characterized by IR,1HNMR and 13CNMR spectra.Thirdly,we researched the asymmetric Diels-Alder reaction of cyclo- pentadiene with acryloyl camphorsultam using different nanometer solid superacids as the catalyst.The yield and the endo/exo ratios of the product under different condictions were studied.We also preliminarily inferred the possible reason that the endo/exo ratios were changed on the presence of catalyst.