| Blood-compatibility is one of the most significant factor that affects the application of the biomaterials. Phosphorylcholine(PC) is one of the most important moieties which compose the cell-membrane and it is of promising application in the field of antiblood-clotting. In this article, a series of poly(lactic acid)(PLA) copolymers are synthesized and the chemical structure, the chemical composing, as well as the working mechanism of the phosphorylcholine content on the hydrophile performance, the protein adsorption and the platelet conglutination are studied.In this article, phosphorylcholine dichloride was got through the reaction of phosphorus oxychloride and choline under anhydrous condition, and then phosphorylcholine poly(ethylene glycol)(PC-PEG) was synthesized which worked as the initiator in the Ring-opening Polymerization to gain the PC-PEG-PLA with the end group of phosphorylcholine. The MPC was synthesized from the Hydroxyethyl methacrylate and phosphorylcholine dichloride, and poly(MPC-g-PLA) as well as the poly(MPC-g-PEG-b-PLA) were synthesized through the free radical polymerization. In addition the poly(MPC)-PEG-poly(MPC) was achieved through the atom transfer radical polymerization (ATRP). And all the copolymers obtained were characterized by the ~1H-NMR.The copolymers mentioned above were solved in chloroform and then films were prepared through the solvent-evaporation which was used to determine the static contact angle, and the result proved that the hydrophilic performance was enhanced with the increasement of the PC and PEG. The minimum contact angle of 8.97°in water was got in the test of the poly(MPC-g-PEG-b-PLA). The test of the platelet conglutination and the antiblood-clotting proved that the introduction of PC and PEG onto the surface of the PLA had no remarkable effect on the Prothrombin Time, yet the large amount of the PC group and polyMPC-PEG can decrease the platelet conglutination effectively.
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