Study On The Organic Reaction Promoted By Manganese(Ⅲ)

During the past decades, radical chemistry has advanced tremendously not only in principles but also in synthetic applications. Especially, in the last twenty years, free radical reactions have become increasingly important, as well as a very attractive tool in organic synthesis. It has attracted many chemists research interest., due to their moderate reaction condition, good regioselectivity and stereoselectivity.This thesis contains three parts. In the first two parts of this thesis mainly focused on carbon radical reaction promoted by Manganses(â…¢):(1) Mn(acac)3 reacted with nitroalkenes underwent ligand-transferring process to synthesize dihydronfuran derivatives, which were further deoxidized of the nitro-group to obtain varies of pyrrole derivatives. (2) Mn(OAc)3 promoted 1, 3-dicarbonyl compounds to react with nitroalkenes to synthesize dihydronfurans with high chemo-, regio- and steroselectivity. The third part of this paper studied mainly on Manganese(â…¢) acetate catalyzed Michael addition reaction of cyclopentane-1, 3-dione with nitroalkenes.The reactions studied in all the three parts of the thesis above possess moderate condition, good regioselectivity and steroselectivity benefits. The structures of products were confirmed by X-ray analysis, 1H NMR, 13C NMR and HRMS spectra. And the possible mechanism was proposed based on these spectra data.