Cyclopropanes Lactam Compounds Of Halogenation Reaction And Its Application

Plant alkaloide, also known as alkaloide, is the bilolgical nitrogen-containing organic compounds, many is medicine treatment.. Quinoline compounds, alkloids occupy a large proportion in natural, most of them have very physiological activity .Furoquinoline alkaloids, widely distributed among plants of the Rutaceae family, have attracted considerable attention because of their diverse pharmacological and boilogical. Cyclopropanes have been studied with numerous inorganic synthesis owing to their efficient and stereoselective ring-open reaction.recently, we has reported a new strategy for the synthesis of line-furoquinolines derivatives in a single step from doubly activated cyclopropane precursors in the form of readily available double cyclopropane compounds. According to our previous work,, we has synthesis a serious of 2-acetyl-2,4-dihalo-N-arylcyclopropanecarboxamides with the corresponding 1-acetyl-N-arylcyclopropanecarboxamides, and further construction of 4-chloromethylfuroquinoline alkaloids.The paper includes the following three aspects:In the first chapter we introduced the background of the research.In the second chapter we have discussed a new synthesis of 2-acetyl-2,4-dihalo-N-aryl- cyclopropanecarboxamides from 1-acetyl-N-arylcyclopropane carboxamides and CuX2(as halogen reagent)In the third chapter our studies were focused on substrates with 1-acetyl-N-aryl-cyclo- panecarboxamides.Tandem annulation/chloronium cation-transfer aromatization reations of chloromethylfuroquinolines derivatives under the H2SO4 mediated reaction condition. Seventeen new compounds were synthesized and characterlized by IR, Mass and NMR (¹H, ¹³C) spectrum in this thesis.