Synthesis And Thermo-Sensitive Property Of Star Poly (N-isopropylacrylamide) With α-D-Glucose-based Group

Polymers containing functional groups of biological activity have a good biological compatibility.A star poly(N-isopropylacrylamide) withα-D-glucose-based group was synthesized via Atom Transfer Radical Polymerization(ATRP) in this dissertation.Furthermore,the kinetics of the polymerization as well as the thermo-sensitive property of the polymer were studied in detail.The Atom Transfer Radical Polymerization of NIPAM was performed in a sealed system filled with nitrogen at 25℃,using Glu-Br prepared by the reaction ofα-D-glucose and 2-bromoisobutyrlbromide as initiator,CuCl and HMTETA as the catalyst system as well as DMF and water(v/v,20/3) as solvent.The study of the kinetics revealed the linearity plot of the M_n,GPC against conversion and the reaction time.The study of the thermo-sensitive property showed that the LCST of the polymer was lowered to 23.9℃,compared to that of PNIPAM(about 32℃).To a certain extent,the LCSTs increased with increasing molecular weight.Furthermore,the LCST of the aqueous Glu-PNIPAM was raised effectively by addingβ-cyclodextrin,which formed an inclusion complex with the polymer.The star polymer had a better ability to accommodate the litlle fluorescein molecule by testing the its inclusion property.