Production And Evaluation Of Transdermal Drug Delivery System For Ligustrazine Phosphate

In this thesis, the production and evaluation of transdermal drug delivery system for Ligustrazine Phosphate are studied by modal and experiments. Chitosan (CS) and alginate (Alg) are chosen to produce an effective drug delivery structure, which has a foreseeable potential in practice using.Firstly, the conditions for producing chitosan membrane is studied and the results show that the proper conditions are as follows:the molecular weight of chitosan should be around 100,000 dalton; chitosan solution of 3.0%(w/w), acetic acid of 2.0%(w/w) and sodium hydroxide of 0.1%(w/w) are mixed and dried to produce the chitosan membrane. To improve the stability and strength of chitosan membrane, extra modification is made and the effect on intensity and permeability is evaluated.A mixture of chitosan and alginate by 1:3 (v/v) is used for producing a much better transdermal membrane, which has a steady and consistent structure as shown by photographs from scanning electron microscope. Ligustrazine phosphate (TMPP) is used as a model medicine to evaluate the ability of medicine permeating through SD rat skin. The influence of different factors (the presence of resolving enhancers, the composition of membrane and the kind of solvent) are investigated and an optimal prescription is achieved. The steady speed of permeation of TMPP is 419.55±72.10cm(ug·cm-2·h-1), and the permeating amount adds to 9637.946±109.38(ug·cm-2) in 24 hours.Problems such as low permeation rate and instability of transdermal drug delivery system for ligustrazine phosphate are solved in this thesis. The CS/Alg membrane of 10cm2 with 20% (w/w) TMPP can meet the requirement of therapy. The results derived in this thesis can be treated as guidance for further reseach.