T-BuOLi-mediated Alkynylation Of Aldehydes

The thesis consists of two parts:The first part is the synthesis of propargylic alcohols, in which it mainly introduces the methods for the preparation of propargylic alcohols and the improvement in the synthesis of propargylic alcohols. Firstly, we mainly introduces the common methods for the preparation of propargylic alcohols. This part mainly focused on the synthesis of propargylic alcohols in many methods including metal acetylides, terminal alkyne derivatives and the direct alkynyl C-H activation. Additionally, the research of propargylic alcohols' asymmetric synthesis was presented. At last, this part ended with what we have done in the synthesis of propargylic alcohols.The second part is the synthesis of amidines. We discussed the application and synthesis of amidines and our study on the improvement in the systhesis of amidines. We synthsised a series of new aromatic amidine compounds in CH2Cl2 at room temperature in air using aromatic enamine and 4-methylbenzenesulfonyl azide as starting materials by conducting (3+2) cycloaddition elimination reaction. Compared with the previous methods, our method reveals several advantages in terms of its simple operation, mild reaction conditions, efficiency, and easy availability and it is environmentally friendly.