Sythesis Of Zwitterionic Water Soluble Chiral Phosphine Ligand

In order to get optically pure compounds, people do a lot of efforts, and the use of chiral catalysts for asymmetric synthesis is one of the most effective ways. But the difficulty of catalyst recovery limits their further application. To solve this problem, this thesis synthesis PPM at first, and then modified PPM to get a new zwitterionic water-soluble and chiral diphosphine ligand. Next, we synthesized BINAP and two BINAP derivatives, and try to modify them at the similar way. This thesis mainly includes :(1)Using 4-Hydroxy-L-proline as the starting material, PPM was prepared in four steps. And then a new zwitterionic water-soluble chiral phosphine ligand with amino acid moieties was prepared. The structure of new phosphine and precursors were identified by 1H NMR,13C NMR and 31P NMR.(2) BINAP was synthesized from BINOL, then using BINAP as the starting material, two BINAP derivatives: 5,5'-Diamino BINAP and 5,5'- Diaminomethyl BINAP were prepared. Finally, the two derivatives was tried to be modified with amino acids at the similar way.