Schiff Base Of Alkali Metal Complexes And Catalytic Activity And Antitumor Activity Research

Objective: By pyridine formaldehyde and benzene 2 amine or ethylenediamine reaction system schiff base ligand, Further and excessive metal cooperate, The formation of certain catalytic performance or the complexes antitumor activity. Study of in the green epoxy processes, And discuss the anti-tumor field in application and action mechanism.Methods: With benzene 2 amine and pyridine formaldehyde as raw material, Through a series of reactions, The formation of a particular activity metal complexes. Using synthetic metal complexes, The fracture of epoxy process and so on, et cetera catalytic. Epoxy electrolyzing process, Metal complexes as catalyst, Use 30% H2O2 for oxygen source, Ring has a series of as the substrate ene reaction; Open loop double faults process, Metal complexes as catalyst, Use 30% H2O2 for oxygen source, Ring has a series of as the substrate ene reaction; In Antitumor, First by MTT method has antitumor activity were the metal complexes, Again through fluorescent titration,Uv absorption spectra,Viscosity means to detect the complexes mechanism of DNA.Results: Experiments prove, By benzene 2 amine and pyridine formaldehyde synthetic ligands with metal complexation again after the ligand formed, In the process of epoxy didn't show activity; The broken key ring opening process, Silver,,cobalt,zinc,nickel corresponding complexes exhibited certain activity; After by MTT screening, Measurement cadmium, zinc, copper, silver correspond complexes has good antitumor activity.Conclusions: Schiff base pyridine formaldehyde class alkali metal complexes, Silver, cobalt, zinc, nickel corresponding complexes open loop to oxidation process with broken key better catalytic role; Cadmium, Zinc, Copper, Silver of the corresponding complexes has good antitumor activity.