Research On The Synthesis And Structure Of Unsymmetrical Macrocyclic Compounds

Nature has evolved an enormous amount of highly specific, hierarchical, selective and cooperative bio-chemistry systems. These bio-chemistry systems are supramolecular systems par excellence. In biological chemistry, the supramolecular hosts are the receptor sites of enzymes, genes, antibodies of the immune system, and ionophores. The guests are substrates, inhibitors, co-factors, drugs or antigens. Much of the inspiration and origins of supramolecular chemistry comes from the chemistry found in living biological systems. A great deal of effort in supramolecular chemistry has been expended in attempts to model or mimic biological processes such as the catalysis of organic chemical reactions by enzymes, or the selective transport of metal cations or molecular substrates such as O2. In recent years, the supramolecular chemistry based on macrocyclic chemistry develops quickly. It is closely related with the new synthetic chemistry, life sciences, new materials and new technology development. In the supramolecular system, the design and synthesis of the host molecular is an important part of the research area. Because the host molecular of the current study is focused on few kinds of compounds, the scope of the study is correspondingly restricted. In order to achieve the purpose of complexing (capturing) of a specific object molecular (ion), the study of designing and synthesizing the new types of host molecular with a number of sites to identify the specific guest molecular (ion) is necessary, and has a very good development. In this paper, we synthesized the following categories of "O" bridge asymmetric "calixarene", and did the research of their structures.1. Through the analysis of miscellaneous bridge Calixarenes that we have known, we designed the "O" Bridge asymmetric "calixarene" series.2. Using catechol, resorcinol, hydroquinone and 2,6-dichloropyrazinethe as raw materials, we synthesized the two asymmetric Calixarene target compounds, and got three symmetric Calixarene compounds, including four compounds which have not been reported. Their structure was confirmed by 1H-NMR,13C-NMR, MS, and the single crystal X-Ray diffraction experiment.