Intermolecular 1,3-Dipolar Cycloaddition Reactions Of Chiral Cyclic Nitrones With Alkenes

Asymmetric 1,3-dipolar cycloaddition reaction of nitrone and alkene is one of the major research endeavors in asymmetric synthetic chemistry in the last few years. The asymmetry of 1,3-dipolar cycloaddition reaction of nitrone and alkene can be controlled by choosing a chiral nitrone, a chiral alkene, or a chiral catalyst(metal-catalyst or organo-catalyst). In this paper we mainly discussed intermolecular 1,3-dipolar cycloaddition reaction of chiral cyclic nitrones and alkenes. This thesis is composed of two parts as below:1. The cycloadducts of asymmetric 1,3-dipolar cycloaddition reaction of nitrones and alkenes-isoxazolidines are important synthetic intermediates in total synthesis of natural product and analogues. This part provides an overview of the most significant advances in asymmetric 1,3-dipolar cycloaddition reaction of nitrone and alkene in the last few years.2. We have reported intermolecular 1,3-dipolar cycloaddition reaction of new chiral cyclic nitrones and alkenes. Under the optimized reaction conditions, the reactions were performed with different nitrones and a set of alkenes, providing the expected products with good yields and poor-to-high diastereomeric ratios.