Study On Mulberry Leave Hypoglycemia Pellet

Mulberry leaves (the leaves of Morus alba), which ware used as medicine and food. Research s hows that the main effect becomes rament glucose-lowering components is flavones, alkaloid and pol ysaccharides composition。Use of mulberry Leave development new hypoglycemia drug is great for i ncrease people health level. This paper introduces the design of mulberry Leave hypoglycemi-a pellet of production technology, This process and process the mulberry Leave hypoglycemi-a pellet on the toxicology research and functional evaluation and quality research.This paper explores the best conditions to to break mulberry leaf cells of vacuum the wall,by or thogonal test. The temperature is 55℃,and keep 15min,then the The pressure drop to-0.01 in 2-3s. The prescription of Mulberry leave hypoglycemia pellet is mulberry leaf 440g and glu-tinous rice 60 g ever 1000 piece.Acute toxicity experimental results show that the mulberry leave hypoglycemia pellet as non-toxic level drugs. Micro test according to the treatment group and control group more positive eosinophilic PCE) and natural red blood cells (mature erythrocytes (RBC) that the comparative analysis, the ratio of bone marrow eosinophilic p-propenylanisole glucose-lowering piece dyed red blood cells micro test for more than negative. Comparative analysis to medicine group and control group of mice, sperm aberration rate conclusion mulberry leaf glucose-lowering piece sperm deformity test results for negative. Mulberry leaf glucose-lowering piece 30 days feed test, general situation observation did not see abnormity; Rats increase heavy, food intake, food utilization, hematology index, blood biochemical indexes saw no adverse effects; The human anatomy, viscera absolute weight and relative weight (dirty/body ratio), observed histopathologically kidney, liver, lienal, stomach, duodenum, testicular, ovarian there were no significant pathological changes.Classics mouth giving mice mulberry leaf glucose-lowering piece 3,1,0.1 g/kg BW d (respectively of adult intake p-propenylanisole glucose-lowering slice 10,30, one times), continuous irrigation, the stomach dose group of 30 days on the normal mice weight and no influence on fasting blood glucose values; 3 g/kg BW of four hydrogen dose group of d elevated mice pyrimidines hyperglycemia model fasting blood glucose lowering rate, reduce blood sugar and reduce fasting glucose 0,0.5 to 5h glucose curve, the area under the role; 1 g/kg BW d can raise dose group of four hydrogen pyrimidine hyperglycemia model mice, reduce the rate of descent fasting glucose to glucose 0,0.5, blood glucose curve 5h next area. On the basis of the inspection and evaluation of health food technical specification for 2003 edition, health food products function assessment procedures and testing method learn standard, the second of three test method learn evaluation function, auxiliary lowering blood sugar function testing method criteria to judge, judge mulberry leaf glucose-lowering piece has auxiliary lowering blood sugar function.This paper exams backflow, ultrasonic wipe soxhlet method, different extraction methods of Mul berry Leave Hypoglycemia pellet polysaccharide and flavonoids of ring, the shadow extraction by col orimetric determination of its content. The simulation results show the ultrasonic method becomes ra ment polysaccharides and measured flavonoids content 1.402% respectively, the highest 2.49%.