The Solid-liquid Equilibrium Of Sclareol In Several Organic Solvents

Ambergris has a comparable reputation with muskiness, civet and castoreum. It is one of the four most valuable perfumes. However, natural source of ambergris is not enough. Many substitutes arise. Ambroxane precursor is considered as the best. Many researchers have given much concern to find what material can be used to synthesize ambroxane precursor. Sclareol has been proved to be the only practicable raw material. Therefore, extracting sclareol from sage clary is of much economic benefits.The solubility data of sclareol in organic solvents play an important guiding role in process designing and equipment choosing. But there is no data in literature. This work will provide the data which could be referenced for further research.Experiment purpose and properties of experiment substance are analyzed and equilibrium method is chosen. The solubilities of sclareol in ethanol, isopropanol and ethyl acetate are measured during the temperature range of 298.15K-328.15K. The experiments show that all the solubilities, whether in the ethanol, in the isopropanol and in the ethyl acetate, increase with temperature. And in the same temperature, the solubility data in the ethyl acetate is bigger than others.The experimental solubility data of the three systems are separately correlated by empirical equation,λh equation and Scatchard-hildebrand equation. The results show that the three equations give good agreement with all the systems and the total average relatively error is less than 3%. The result ofλh equation correlation is better than the others. When without experiment data in the certain temperature, we can predict it by usingλh equation.At last, this work estimates the solubilities of sclareol in ethanol, isopropanol and ethyl acetate by using UNIFAC model. That is, separating the sclareol molecular to several groups, computing each group's contribution to solubility through the interaction between groups and summing all the contribution to obtain the solubility data of the whole molecular in the each solvent. Comparing the estimated data with experiment data shows that the total average relatively error of 10% exists. This may attribute to the purity and the molecular construction of sclareol. As result, using UNIFAC for describing sclareol's solubility in solvents can only be for conference.