Studies On The Acylation And Sulphuration Reactions With Disulfides

The formation of C-S bond is an important tool in organic chemistry. C-S bond can be found in many molecules that are of biological, pharmaceutical. A series of reactions promoted by rongalite? and N-bromosuccinimide have been studied. This thesis consisted of two parts. The first one is focused on the synthesis of thioesters and selenoesters from the acylation of anhydrides with disulfides in the presence of Rongalite?. The second is focused on the synthesis of 3-sulfenylindoles from sulphuration of indoles with disulfides promoted by N-bromosuccinimide.In part one, the synthesis of thioesters and selenoesters in organic chemistry was reviewed. In the presence of Rongalite?, the synthesis of thioesters and selenoesters from the acylation of anhydrides with disulfides was studied. The remarkable advantages of this reaction are metal-free catalyst, simple operation, mild reaction conditions, high yields, avoiding the use of odor substrates such as thiols. The process meets the demands of the green chemistry to the organic synthesis.In part two, the synthesis of sulfenylindoles in organic chemistry was reviewed. N-Bromosuccinimide-promoted synthesis of 3-sulfenylindole derivatives from sulphuration of indoles with disulfides was studied. The important features of the methodology are metal-free catalyst, high yields, simple operation, and no requirement for additive and avoiding the use of odor substrates such as thiols.