The Coupling Reaction In The Synthesis Of Trifluoromethyl Contained Compounds

This paper includes five parts. The main research purpose is to develop some new methods for the synthesis of new trifluoromethyl-contained compounds using the C-C, C-O, C-N or C-S bond forming reactions.(1) Some commonly methods were reviewed for the formation of the basic chemical bonds, such as C-C, C-O, C-N, and C-S bond forming reaction. Compared with C-S bond forming reaction, there are many famous methods for the previous three bonds formation, and the papers of the carbon-sulfur bond formation are less. Thus, three methods are summarized for the carbon-sulfur bond formation.(2) The Pd(PPh₃)₄-catalyzed coupling of (2-chloro-3,3,3-trifluoroprop-1-en-1-yl)- benzene with phenylboronic acid has been reported, and the effects of different groups has been discussed.(3) FeCl₃-catalyzed coupling reactions of 2,2,2-trifluoro-N-phenylacetimidoyl chlorides with benzenethiols under mild conditions have developed for the synthesis of CF3 contained vinyl thioether.(4) 2-(Trifluoromethyl)benzo[b]thiophene, 2-(trifluoromethyl)benzo[d]thiazole and their derivatives were synthesized by 1-halo-2-(2-chloro-3,3,3- trifluoroprop-1-en-1-yl)benzene coupled with Na₂S, and N-(2-halophenyl)-2,2,2-trifluoroacetimidoyl chloride coupled with NaSH using CuI catalyst.(5) The synthesis of 1-(trifluoromethyl)-1H-isochromene and its derivatives has been reported using o-alkynyl benzaldehyde and CF3TMS as the reaction partners. It is noteworthy that the reaction is carried out in the presence of water under metal-free conditions.