| In this paper, the formulation and manufacturing technology of an osmoticpump type sustained release tablet using Salbutamol as a model drug wasevaluated. In the core tablet, NaCl was used as an osmotic pressure increasingagents. PEG was added as pore forming agent and Tween-80 as plasticizer to thefilm forming agent cellulose acetate. The pore perforated by laser was used forthe drug release. The thickness and the diameter of the pore on the coated filmwere the key factors determining the in vitro drug release. For the optimizedformulation and technology, the weight increase per tablet was 12~14 mg and thepore was 200 400 mFor the samples prepared the scaled technology , there in vitro drug releasewere compared with those of British made tablet with a brand name"Valmax".The results showed that there was a significant similarity between the two in vitrodrug profiles.In this paper, the assay and analysis of the related substance were tested usingHPLC. The stability of the sample was tested at the accelerated conditions as hightemperature (40±2 )and high humility(75%±5%) for 6 months, the resultsshowed that the samples are stable.The osmotic pump type sustained release tablet using Salbutamol as a modeldrug could be an alternative for the imported tablet"almax".
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