Chiral Analysis Of Solid Phase Extraction Based On Metal - Organic Skeleton Materials

The main works of this dissertation were summarized as follows:Chirality, meaning of chiral separation, optical resolution methods, solid-phase extraction, rapid determination of enantiomeric excess were introduced.A chiral MOF [Zn2(D-Cam)2(4,4′-bpy)]n(D-Cam = D-Camphoric acid, 4,4’-bpy = 4,4’-bipyridine) with 2-D homochiral layers was used as material of solid-phase extraction to analyze binaphthol, C18 chromatographic column was used to analyze the total concentration of eluent. The effects of various factors on the extraction column performance were also investigated. There was a good linear relationship between the enantiomeric excess(e.e. %) of feed samples and the total concentration(C) of eluent from extraction column. A quantitative determination of e.e. % of chiral compounds with excellent reproducibility, stability and accuracy was achieved.Chiral MOFs{[Co(L-tyr)]n(L-tyrCo)}(L-Tyr = L-tyrosine) was also used in solid-phase extraction to analyze binaphthol. UV-visible spectrophotometer was used to analyze the total concentration of the eluent. After optimized various operation conditions, we obtained a good linear relationship between the e.e. % of feed samples and the total concentration of the eluent of extraction column. This method also achieved a quantitative determination of e.e. % of chiral compounds with excellent reproducibility, stability and accuracy.Binaphthol and Troger’s base could be extracted by MOFs {[Co0.5Zn0.5(LTyr)]n(L-tyrCo/Zn)},(L-Tyr = L-tyrosine) with chiral recognition characteristic. The relationship between the e.e. % of feed samples and the total concentration of eluent was studied, too.