Characteristic Of Modified Electrode And Analysis Of Some Medicine

The research of medicine molecule by the electrochemical method has become an important part of analytical chemistry in developing. The primary purpose of this paper is to investigate chemical modification of glassy carbon electrode surface and the electrochemical behavior of antibiotic ofloxacin and neurotransmitter dopamine, and to established new and sensitive electrochemical methods for pharmaceutical analysis. It includes three chapters as follows:Chapter 1:The advancement for medicine study byelectrochemical methods, chemical modification of glassy carbon electrodes and their application in pharmaceutical analysis was reviewed,Chapter 2:A novel differential pulse stripping voltammetry was developed for the determination of the ofloxacin content in the medicament by the differential pulse stripping voltammetry using a poly(crystal violet) film-modified glassy carbon electrode. Electrochemical behaviors of ofloxacin on the modified electrode were investigated by cyclic voltammetry and differential pulse stripping voltammetry. Comparing ordinary glassy carbon electrode, the modified electrode can increase the response of electrochemical signal. The ofloxacin content in the meaicaments was determined by the differential pulse stripping voltammetry. The proposed method has high sensitivity and precision, and can be applied for routine analysis of ofloxacin medicaments.Chapter 3:The electrochemical behavior and catalysis mechanism for dopamine and ascorbic at an activated roughened glassy carbon electrode was studied. A sensitive and selective method for the determination of dopamine and ascorbic acid was developed. The effective separation of dopamine and ascorbic acid was achieved by the activated roughened glassy carbon electrode prepared by potential recycling in a 0.2 M aqueous solution of NaOH. The detection limit of dopamine and ascorbic acid was 0.08 and 0.6μM, respectively. The proposed method has advantages of low cost, facility and high sensitivity, and was applied for the determination of dopamine and ascorbic acid in synthetic sample with satisfactory result.