Studies On The Pharmacokinetics Of Selenium And It's Influence On The Oxidant Defense System In Piglet

In this paper the pharmacokinetics of selenium in blood and dynamic regularity of itsantioxidation in the body of the health piglet were systematically studied for the first timeby means of the experiment under conditions that 0.2 mg/kgBW or 0.6 mg/kgBW ofsodium selenite were respectively used for im and po as the single dose. The results wereas follows:1.The characteristics of blood-pharmacokinetics conforms to 1-absorption and 2-department open model, the theoretical equation wasC＝Ae^-αt＋Be^-βt-(A＋B)e^-Katthe main parameters: for im, the half -life of absorption (T_1／2KA) was 0.0499 hrs, the time ofreaching maximum concentration (T_p) was 0.4237 hrs,the half -life of elimination (T_1/2βwas 27l .9311 hrs,the area under the curve (AUC) was 3l.7260 Mg/L.h, and the volume ofdistribution (V_d) was 2.4721L/kg; for po, the time of reaching maximum concentration(T_p) was 2.1517hrs, the half -life of elimination (T_1/2β was 510.2706 hrs, the area underthe curve (AUC) was 75.1460 Mg/L.h, and the volume of distribution (V_d) was 5.5742L/kg.2.The parameters of multiple doses were calculated for clinic treat based on thekinetic parameters of the single dose. For im, loading dose (D^*) was 0.5089 mg/kgBWmaintenance dose (D₀) was 0.2mg/kgBW, dosing internal (Ï„) was l92 hrs, and meansteady state blood level (C) was 0．1652μg／ml; For po, loading dose (D^*) was 1.2262 mg/kgBW, maintenance dose (D₀) was 0.6 mg/kgBW dosing internal (Ï„) was 480 hrs, and meansteady state blood level(C) was 0.1566μg／ml.3.The oxidant defense system in the health piglet varied along with the change of Selevel in the body and had an obvious lag time comparing with the latter. Theantioxidtion did nOt been immediately enhanced when a certain quanity of Se was supplied.Both SOD and TAOC began going up considerably after a longer period but GSH-Pxwas firstly fell down and then increasingly rose uP. The change in MDA was aPparentlylater than that in Se density.This showed that there was regular irmer link betWeen theoxidant defense system and Se concentration.