Pharmacoknetics And Residual Characteristics Of Two Kind Of Antibacterial In Two Kind Of Aquatic

This article could be divided into two parts, one part first reports the residual characteristics of SMZ and TMP in perch at different temperature following oral administration for 5 consecutive days. The concentrations of medicament were determined by High Performance Liquid Chromatography. The results indicated that The velocity of elimination and absorptivity changed at different temperature. They will increase when the temperature increase. The withholding period for perch after oraladministration at dose of 40mg kg-1 with mixture of SMZ and TMP (5/l)for 5 consecutive days should be 26d and 30d at water temperature 22℃ and 16℃.The other part part first reports pharmacoknetics of enroflxacin and its activated metabolite ciprofloxacin in Penaeus chinensis. after intramuscular injection. The concentration of medicament were determined by High Performance Liquid Chromatography. The data were analyed with the pharmacoknetics computer program MCPKP. The pharmacyoknetic showed that the concentration-time course of enroflxacin in plasma after intramuscular injection can be described by a two-compartment open model. The main pharmacoknetics parameters were as follows: T,/2 a 0.094h, T1/2B 7.03h, AUC 39 Mg/L.h, K12 3.59 h-1 , K21 3.69h-1. The theoretical equation was C血液 =3.93e-738t+3.83 e-0.1t. the concentration-time course of enrofioxacin in muscle and liver can be described by a two-compartment open model too. The main pharmacoknetics parameters were as follows: AUC 73 and 320 Mg/L.h > T1KA 0.03and 0.06h, T1/2 B 19.7 and 59.7h. The theoretical equation was C 肌肉 =4.379e-0.4t+2.57e-0.03tt-6.949e--22.73t, C 肝胰脏=8.99e-0.142t+3.44e-0.013t-6.949e-11.95t, Ciprofloxacin, The metab -olite of enrofioxacin can be detected in all three tissue. The values of main pharmacoknetics parameters Cmax(ug/ml),AUC(mg/L.h),T1/2KA(h)and T1/2K(h) were as follows: 0.009,1.26,0.17 and 10.3 for muscle, respectively, 0.023,0.95,0. 14and 13.3 for blood, respectively, 0.183,18.7,2.34 and 20.7 for liver, respectively. Base on the data above, we suggest dosage regimen of enrofioxacin is that Penaeus chinensis can take enrofioxacin once one day by intramuscular injection (6.4 mg/kg)...