Clinicopathological Features Of Triple - Negative Breast Cancer And Non - Triple - Negative Breast Cancer And Expression And Significance Of ERβ And

Objective This study aims to analyze the differences in clinicopathologic features and ERβ, EGFR, P53and Ki67expression between triple negative breast cancer and non-triple negative breast cancer.Methods863patients with breast cancer which confirmed by histopathology were collected in Peking Union Medical College Hospital from January2010to December2013. We retrospectively analyzed the differences in the onset age, histological subtype, maximum diameter of the tumor, tumor differentiation, tumor stages, lymph node metastasis, nipple involvement and operation mode between triple negative breast cancer and non-triple negative breast cancer, then explored the differences between triple negative breast cancer and non-triple negative breast cancer in the expression of ERβ, EGFR, P53and Ki67by immunohistochemical staining. The relevant factors which affected the prognosis of triple negative breast cancer were further discussed by univariate survival analysis.Results The proportion of invasive ductal carcinoma in triple negative breast cancer was higher than non-triple negative breast cancer (P<0.01); the age of onset was younger in triple negative breast cancer (P<0.05); and there were significant differences in lymph node metastasis, tumor sizes, differentiation grade, tumor stages between them (P<0.05); There were no statistical significance in nipple involvement (P>0.05). Immunohistochemistry results showed that, compared with non-triple negative breast cancer, ERβ expression rate decreases significantly while EGFR expression rate and was significantly increased in triple negative breast cancer (P<0.05); the expression of P53and Ki67had no significant differences (P>0.05); the overall surviva (OS) and relapse free survival (RFS) was lower in triple negative breast cancer (P<0.01). Univariate survival analysis showed both ERβ negative expression and EGFR positive expression were related to the poor prognosis of triple negative breast cancer (P<0.05).Conclusion Compared to non-triple negative breast cancer, triple negative breast cancer shows completely different clinicopathologic features:younger age of onset, larger tumor size, higher incidence rate of lymph node metastasis, lower ERβ expression, EGFR higher expression, and lower OS and RFS.ERβ and EGFR may be important prognostic indicators of triple negative breast cancer.