Study On Functional Connectivity Of Functional Resonance Magnetic Resonance Pyramidal System In Normal Subjects

Part â… :Study of the red nucleus and substantia nigra functional connectivity maps in the normal adultsObjective To investigate the functional networks in the pattern of functional connectivity (FC) within whole brain between the red nucleus and substantia nigra in healthy subjects using the resting-state functional magnetic resonance imaging (fMRI).Materials and Methods Twenty normal subjects were performed resting state fMRI scanning and susceptibility weighted imaging. The function connectivity networks base on seed regions of the red nucleus and substantia nigra were extracted from low frequency fluctuation signals in fMRI data by using a temporal correlation method. Individual functional maps were entered two-tailed one-sample t test to determine brain regions with significant positive correlation to the seeds. The statistic threshold was set at P<0.001, cluster size>42(336mm3), cluster connectivity criterion5rmm with Alphasim correction.Results Brain regions involved in the functional connectivity network of the red nucleus include: supramarginal gyrus, supplementary motor area, the ventrolateral and the ventromedial nucleus of the thalamus, globus pallidus, dorsal thalamus, hippocampus, substantia nigra, red nucleus, pons, dentate nucleus, vermis; Brain regions involved in the functional connectivity network of the substantia nigra include:anterior cingutate, supramarginal gyrus, globus pallidus, dorsal thalamus, hippocampus, lobus insularis, substantia nigra, red nucleus, pons, dentate nucleus. The distribution of the networks of the red nucleus and substantia nigra presented symmetrical. Although the functional networks of the red nucleus and substantia nigra overlaped largely with each other, the rubral network was slightly different with the nigral network, witch showed strong correlations with more wide-spread striatum and thalamus areas.Conclusions The functional networks of the red nucleus and substantia nigra reflected strong interplay within the extrapyramidal subcortical system, as well as correlations between some limited cerebral cortices; Functional magnetic resonance imaging is a potential powerful tool to explore the extrapyramidal system. Part â…¡:Resting-state functional connectivity map of dentate nucleus in healthy subjectsObjective To investigate the functional networks in the pattern of functional connectivity (FC) of dentate nucleus in healthy subjects using the resting-state functional magnetic resonance imaging(fMRI).Materials and Methods Twenty normal subjects were performed resting-state fMRI scanning and susceptibility weighted imaging. The function connectivity networks base on seed regions of the left and right dentate nucleus were extracted from low frequency fluctuation signal in fMRI data by using a temporal correlation method. Individual functional maps were entered two-tailed one-sample t test to determine brain regions with significant positive correlation to the seeds. The statistic threshold was set at p<0.001, cluster size>42(336mm3), cluster connectivity criterion5rmm with Alphasim correction.Results Brain regions involved in the functional connectivity network of the left dentate nucleus include:the right and left cerebellum hemisphere, tonsil of cerebellum, vermis cerebellum, dentate nucleus, brainstem, thalamus, lenticular nucleus, lateral dorsal nucleus, pallidum, pons, insula; Brain regions involved in the functional connectivity network of the the right dentate nucleus include:the right and left cerebellum hemisphere, tonsil of cerebellum, vermis cerebellum, pons. The distribution of the networks of bilateral dentate nucleus presented symmetrical.Conclusions The functional networks of bilateral dentate nucleus mainly overlaid the structures of extrapyramidal system including cerebellum cortex, brainstem, thalamus and some limited cerebral cortices. The connectivity map of dentate nucleus reflected the conformity between structural and functional networks. The connectivities within the extrapyramidal system could be evaluated by measurement of the dentate nucleus fMRI temporal signals.