| Objective:To observe the clinical efficacy and safety Wenyanghuoxue Chinesemedicine-free fried particles in combination with Sarpogrelate hydrochloride (Anplag) in the treatment of arteriosclerosis obliterans of early lesions, in a randomized controlled trial with Sarpogrelate hydrochloride in combination with aspirin (ASA).To explore a new mode of combined therapy of Chinese and Western medicine in the early ASO,and improve the The efficiency of the early stage of the disease in clinical treatment.Method:During the selection China Academy of Chinese Medical Sciences Wangjing Hospital outpatient surgery and vascular surgery clinic from 2014 January to 2015 February in accordance with the inclusion criteria of patients with ASO. Were randomly divided into experimental group 23 patients with 26 limb and control group 22 patients with 27 limb. The two group were treated with oral sarpogrelate hydrochloride (anplag) 100mg, three times a day. In the test group oral sarpogrelate hydrochloride and oral administration of Warming Yang and Invigorating Qi, promoting blood circulation to remove meridian obstruction free frying granules, a agent. Patients in the control group oral Aspirin Enteric-coated Tablets 100mg, once a day, and of sarpogrelate hydrochloride (anplag) 100mg, three times a day. In 4,8 weeks after the acquisition and analysis of the changes of symptom scores of patients, ABI, coagulation, liver and kidney function etc.Application of SPSS19.0 for statistical analysis. Gender and treatment using frequency count. Measurement data using mean (reserved to percentile) expression. In the following additional standard deviation (reserved to percentile) improve data accuracy. The basic value data according to whether accord with normal distribution respectively by t test and quality inspection of nuclear judgment; data application test, contrast two groups in zeroth weeks, eighth weeks of the acquisition of the paired sample t test to compare the difference of effectiveness. The validity of the data application independent t test for test, control between the two groups was zeroth weeks, eighth weeks of collected differences. The final evaluation of the effectiveness of the treatment in the two groups.Results:1 The two groups suffered almost equallyTwo groups of patients are comparable in sex, age, body mass index (BMI), heart rate, blood pressure, symptom score and ankle brachial index (ABI), coagulation function, liver and kidney function, no statistical significance between the two groups (P> 0.05).2 Improving the situation of two groups of symptoms after 8 weeks of treatmentThe experimental group of 23 patients, included 26 limbs. The control group of 22 patients, included 27 limbs. Two groups of symptoms and signs points before treatment (P> 0.05) have no statistical significance. After the treatment of 4,8 weeks, two groups of symptoms compared with those before treatment are reduced.3 The comparison of the ankle brachial index in two groups of 0 weeks and 8 weeks of treatment.The experimental group 26 limbs of the ankle brachial index at the beginning is 0.81+0.02, after 8 weekstreatment improve into 0.90+0.04, control group 27 limbs of the ankle brachial index at the beginning is 0.79 ± 0.03, after 8 weeks treatment improve into 0.86 ± 0.03. The experimental group before treatment and 8 weeks after treatment of ankle brachial index difference (P< 0.01) there was significant; control group before and after the 8 weeks treatment of ankle brachial index difference (P> 0.01) were statistically significant; after 8 weeks of treatment, a total of 53 side limb ankle brachial ratio difference (P> 0.05) there were no statistical significance.4 The treatment of the two groups before and after the safety evaluationDuring the treatment 45 cases selected patients every safety index is always in the normal range, no obvious abnormal change, change had no statistical significance (P> 0.05). Observation of treatment did not arise during critical events, no drug adverse reaction and allergic reaction occurredConclusion:1 Compared with the conventional sarpogrelate hydrochloride in combination with aspirin treatment, combined with The Wenyanghuoxue Chinese medicine can effectively relieve patients with rest pain and limb skin cold, numbness of the limbs and other symptoms, prolong the claudication distance2 Compared with the conventional sarpogrelate hydrochloride combined with aspirin in the treatment of traditional The Wenyanghuoxue Chinese medicine can improve the limb ankle brachial index3 The Wenyanghuoxue free frying granules Combined with sarpogrelate hydrochloride for the treatment of arteriosclerosis obliterans early lesions is safe. |
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