A Retrospective Study Of Intravitreal Perfusion Of Cinobufacini In The Treatment Of Malignant Serous Effusion

[The purpose of the study]Through clinical research observed the natterjack hormone injection cavity perfusion treatment of malignant serous cavity effusion quantity and quality, clinical symptoms,physical condition to improve the situation,and differences in the efficacy of more malignant pleural effusion, malignant ascites,malignant pericardial effusion, statistical analysis primary disease conditions,fluid properties and the effect of correlation product,better guide clinical treatment.[Research methods]Based on the literature review of malignant effusions and pathogenesis of Chinese treatment,using the method of retrospective study, observation of patients with malignant serous effusion using cinobufacini injection cavity perfusion before treatment (3 days) to seventh,14 days after treatment of the effusion quantity and quality changes, the score before and after treatment of TCM the symptom score and physical status (KPS score) changes; and stratified observation of different perfusion way (pleural perfusion, peritoneal perfusion, pericardial perfusion), the incidence of different conditions (including location, pathology, metastasis), different effusion (exudate and transudate, local syndrome of dampness heat toxin and local cold dampness toxin syndrome the effect of difference). The observation of the amount of effusion was prolonged to 1 months, the observation of adverse drug reactions throughout the observation period. Using SPSS 20 statistical software, the establishment of the database and its statistical analysis.[The results of the study]lEfficacy evaluation of effusion volume:134 patients, complete remission in 13 cases, partial remission in 22 cases, stable in 54 cases,45 cases were ineffective, the effective 66.42%. The pericardial infusion in group 6 cases were effective, but due to insufficient sample size, only preliminary explora- tion of the effect,were not statistical ly compared, peritoneal perfusion group, the effective rate was 66.67%, pleural perfusion group, the effective rate was 63.24%, a comparison between the two p> 0.05, the difference was not stati-stically significant. According to the original incidence statistics: ①The incidence of the disease:because of the number of diseases in the case of the disease is not equal, it is difficult to compare the effect between the single disease, so the problem analysis of the main disease effect;② The pathological nature:according to the pathological nature of the stratification, the differ-ence was not statistically significant;③ Metastasis:the efficacy of serous serous effusion with serous serous effusion is better than that of malignant serous effusion (P< 0.05). According to the nature of effusion statistics:① Exudative groups with efficiency higher than transudate group efficiency, but not because of the two baseline, the difference cannot do statistical analysis, to further expand the sample size to explore.②According to the local Chinese medicine syndromes stratified statistical, damp heat toxin syndrome efficiency 71.57%, cold dampness toxin syndrome efficiency is 50%, a comparison between the two P< 0.05, the difference was statistically significant.2Evaluation of curative effect of fluid matter:134 cases of malignant serous cavity effusion patients treated with cinobufacini injection cavity treatment, red blood cell (RBC), lactate dehydrogenase (LDH), tumor marker (TM) levels decreased after treatment, and after treatment than before treatment, RBC level decreased more than 25% accounted for 54.48%, LDH decline in more than 25% accounted for 53.73% and TM decreased more than 25% accounted for 54.48%.3Cinobufacini injection cavity infusion of Chinese medicine symptom score after treatment by (11.39±3.57) reduced to (8.91±2.76) before and after treatment comparison, P< 0.05, the difference was statistically significant. Cinobufacini intravesical instillation of KPS score after treatment with before treatment (51.27±1.1) up to (59.04±1.2) before and after treatment comparison, P< 0.05, the difference was statistically significant4The study included 134 patients received Huachansu injection cavity perfusion in the treatment of malignant serous cavity effusion patients during treatment in January there was no drug-induced bone marrow suppression, liver and kidney damage, arrhythmia and other serious adverse reactions. The main side effects were found for pain, fever, diarrhea, the incidence rate was 15.67%(21/134), 14.18%(19/134),11.19%(15/134).[The conclusion of the study]① Hua Chan Su cavity perfusion from the effusion of "quantity" and "quality" in the treatment of malignant serous cavity effusion, efficacy, adverse reactions, it is worth further study and application.② Cinobufagin (intravesical treatment of malignant serous cavity effusion on the serosal transfer, local syndrome of dampness heat toxin the better effect, of the differences in the efficacy of different pathological nature was not significant, prompted the natterjack plain intravesical treatment of malignant serous cavity effusion should be based on local syndrome differentiation, both the overall disease differentiation.③ Cinobufagin hormone injection cavity perfusion treatment mechanism of malignant serous cavity effusion may to change the capillary permeability of the membrane, the impact of the VEGF and VEGFR signal transduction pathway.④ Hua Chan Su intravesical infusion therapy can improve the symptoms and increase the physical condition of patients,indicating that the natterjack plain intravesical infusion therapy may improve the patient’s quality of life to a certain extent.