| Aims:Frequent premature ventricular complexes (PVCs) can cause progressive left ventricular dilation, but not all patients with frequent PVCs will develop ventricular dilation We sought to determine the incidence, clinical and electrophysiologic characteristics, and the predictors of PVC-mediated LV dilation。Methods:Three hundreds patients who underwent radiofrequency catheter ablation(RFCA) for frequent PVCs between 2012.1-2013.1 and had no significant structural heart disease were investigated。All patients underwent N-terminal pro-brain natriuretic peptide(NT-proBNP) test and had 12-lead surface ECG and Holter monitoring to evaluate multiple morphologies and to calculate the PVC burden。Baseline echocardiography was performed within two months preceding the RFCA procedure。LV dilation was defined as LVEDD>55mm for male and >50mm for female。According to LVEDD, ALL patients were divided to two groups to determine the possible predictors of the PVC-mediated LV dilation。Results:Twenty-one(7%) patients were included in LV dilation group, compared to the LVEDd normal group, male (71.4% vs 29.6%, P=0.0035), PVC frequency (32742±14106/24h vs 21740 ± 10089/24h,P=0.0031), PVC burden (27.46% ± 12.36% vs 20.42% ± 9.15%, P=0.03), PVC QRS width/sinal QRS width (2.01 ± 0.27 vs 1.71 ± 0.22, P=0.0001), LVEF prior to ablation (57.48%±6.47% vs 62.07% ± 3.10%,P=0.005) were significantly different between the two groups。The NT-proBNP prior to ablation, PVC QRS width, PVC morphology, the origin sites of PVCs and the presence of retrograde P-waves were similar。Conclusion:Males are more prone to develop ventricular dilation, The mean PVC burden and PVC frequency were significantly greater in those with LV dilation and with lower LVEF. Earlier diagnosis and treatment are very important for these patients, because when the related PVCs were suppressed LVEDd can decrease to normal level。Background: Frequent premature ventricular contractions(PVC) are frequently encountered in clinical practice. PVCs might be associated with left ventricular(LV) dilation, to what extent LV dilation might be decreased by catheter ablation of frequent PVCs still remain unclear。 The aim of.this study was to determine the degree of recovery of left ventricular end-diastolic diameter(LVEDd) postablation。Methods:In a consecutive group of 300 patients referred for ablation of frequent idiopathic PVCs between 2012.1-2013.1, transthoracic echocardiograms were used to assess left ventricular diameter。 LV dilation was defined as LVEDd>55mm for male and LVEDd>50mm for female in the absence of any detectable underlying heart disease。 Patients underwent transthoracic echocardiography for LV size and function at 1-3 months to 6-12 months of follow-up。Results:Twenty-one patients(15M/6F) with LV dilation were included in the study。 Average baseline LV end-diastolic diameter was 57.48±3.09mm。 Except three patients whose PVCs were treated unsuccessfully by RFCA or that recurred and one patient whose ablation site was LV, in 17 patients, whose LV end-diastolic dimension(LVEDd) measured by echocardiography decreased significantly (57.48±3.09mm vs 52.38± 3.54mm, P<0.0001) with improvement of left ventricular ejection fraction postablation within one year。 There was no association of the degree of postablation LVEDd decrease with the site of origin of PVCs。 The overall mean decrease from baseline in LVEDd postablation was -2.75±4.03mm in patients with hypertension(HT), the mean decrease of LVEDd in those patients without HT was -6.40±3.04mm, but there were no significant difference between the two groups (P=0.0614)。Conclusion:Frequent PVCs were associated with LV dilation, radiofrequency catheter ablation(RFCA) has proven to be safe and successful for curing various forms of PVCs or VT, LVEDd can decrease to normal level postablation。...
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