Study On TCM Syndrome Of Female Knee Osteoarthritis

Objective:To analyse the distribution characteristics of the patterns of female osteoarthritis of the knee syndrome.To ascertain whether there is some difference between the distribution of the patterns of syndrome in ag es and physiological stages. To ascertain the relativity between different p atterns of syndrome in age and the course of disease. To provide bases for c linical treatment to increase efficiency.Methods:1.Literature searching of recent TCM researches on KOA. Summar izing the distribution characteristic of pattern of syndrome of knee OA. 2. Retrospective studying on the casebooks of the 144 patients who are judge d conformity.Collecting the mainly informations.such as the age, the courses of the disease, the symptoms and clinical signs and so on. Symptoms and sig ns are chosen according to". Chinese, medicine clinical research guiding prin ciple"," The standard of curative effect of Chinese traditional medicine".a nd the main symptoms of meta-analysis symptoms in literature sorting. On th e selected symptoms quantify, symptoms of positive are taken as 1,negative taken as O.then making relative data questionnaire. Using epidata3.0 chines e version to input datas.we can get the corresponding data table. Using sps s19.0 system clustering analysis, we can get the results. According to the result of the dendrogram. First, dividing the whole group into 3 parts acco rding to the female physiological stages.Second, dividing the group into 3 parts according to the age. rding to the different grouping methods correspo nding evidence type distribution characteristics, then make a simple compar ison between the two. According to the Statistical analysis we can find is there any differences between the four patterns of syndromes on age and cou rses. Analysing the relationship between pattern and age and between patter n and course. If P<0.05,we think that the difference is statistically sig nificant.Results:1. By using Meta-analysis on the included 22 articles about TC M knee OAs,found the amount of the syptoms onset is 68,the total occurrenc e frequency is about 29196times. Concluding all the symptoms which appeared >1%, we can get the main symptoms of KOA are as follows:stabbing pain of the knee, joint dysfunction, joint swelling pain, arthroncus, Wet weather aggravate,sensation of chill, joint deformity, lack in strength, pulse hea vy string, etc. all the sydromes is regulated into 17 kinds, the total amoun t of which is 1638. Concluding all the sydromes which appeared>7%,the deta ils are as follows:the deficency of liver and kidney syndrome, cold dampne ss bizu, kidney Yang deficiency syndrome, qi deficiency syndrome, qi and bl ood stasis.2. Analyzing the medical records of 144 patients,there are totally 77 statis tical symptoms, which appeared about 1788 times. The frequency of 43 sympto ms is more than 1%, including joint stabbing pain, joint swelling, joint de formity, difficulty in squatting up and down, joint flexion and extension, sensation of chill,lack in strength, Wet weather aggravate Numbness of limb s, Menses amounts are few and so forth, the symptom such as is consistent w ith the results of meta-analysis. Clustering the 37 symptoms whoes frequenc y is more than 14% of the overall cases,we can get a dendrogram. We can div ide all the symptoms into about two three and four types according to the d endrogram. For two clusters, the results are divided into kidney deficiency +Yang haemorrheological nature blood stasis sydrome; For three clusters,i t is liver and kidney Yin deficiency syndrome, cold dampness bizu.blood st asis syndrome. For four clusters, it is liver and kidney deficiency syndrom e, spleen and kidney Yang deficiency syndrome, cold dampness bizu.blood st asis syndrome.By testing the results, I found that it is more meaningful to divide the symptoms into four groups, in this case the P (double sides)< 0.05, showing that the classification is more significant. Based on the fou r groups,the patients are divided into three types according to perimenopau sal period, that is before the perimenopausal period,the perimenopausal pe riod.post the perimenopausal period. Anaylysing the four kinds of symdrome types in the distribution characteristics of three different periods. It c omes that cold dampness arthralgia certificate before perimenopausal period is given priority to,54.5%; liver and kidney deficiency syndrome in perim enopausal is the most for about (34.8%), blood stasis after the menopausal transition by 45.6%. dividing the patients merely on age into three groups, the highest frequency in the first set of evidence for cold dampness bizu certificate, accounting for 37.5%. The highest occurrence of the second and third group were as qi deficiency blood stasis,38%,51.2% respectively. T hen analyzing the different kinds of sydromes by age and disease courses re spectively, found that the types of syndrome have something to do with the age rather than the courses.the p of the age is P< 0.05 (H=7.97,), show ing there has statistically significant. On the contray, Course of the dise ase in pattern distribution has no obvious differences (H=1.347, P>1.34 7).Conclusion:1. The main pattern of knee OAs are the deficiency of liver and kidney and the mixed.it exectly answers the characteristic of this dieases.that is the deficiency in origin and excess in superficial ity. The disease who belongs to the liver, spleen and kidney, in the main disease sex respect are wind, cold, wet, hot phlegm, blood stasis,and the deficiency of qi, and qi stagnation, Yang and Yin.2. The basic. KOA TCM of female are qi deficiency syndrome、blood stasis syndrome、 the yang deficiency of spleen and kidney, kidney deficiency syndrome, cold dampness bizu. And the study shows that it is more meaningful to divide the patients by female physiology periods than barely on age. And the distribution of different characteristics of the patterns have some relations with the length of age rather than the dieases courses. The TCM syndrome distribution of KOAs of Female is different form that in the whole KOAs patients.