Clinical Study On The Effect Of Phlegm - Dampness Physiology On Impaired Fasting Glucose

Objective:From the point of view of phlegm-dampness constitution,we interfere wi th impaired fasting glucose by the way combined the Chinese medicine and healthy ife styles.The medicine is developed by professor Wang Qi rewarded as the National TCM master.The phlegm-dampness constitution without 1FG was treated with NO.1 formula, and the one with IFG was treated with NO.2 or NO.1+2 formula, To observe and ev aluate the clinical safety and efficacy of the medicine.Methods:This study adopted a prospective non-randomized controlled clinical trial. The Volunteers with phlegm-dampness constitution were recruited from Hongyitang during june and November in 2014.According to the result of fasting plasma glucose test,the Volunteers were divided into Group A with normal fasting blood glucose, Grou-p B and Group C with IFG.Each large group was divided into treatment group and control group according to the voluntary principle.The treatment group was given the Chinese medicine and guidance of healthy lifestyles.The one of Group A was given NO.l formula, and Group B given NO.2 formula, Group C given NO.1+2 formula.The conctrol group was given guidance of healthy lifestyles only. There were 157 Voluntee rs recruited. The test took 2 months. Before and after study, relevant indicators were evaluated.Results:After study, Group A has 30 cases in treatment group,21 cases in control group. Group B has 28 cases in treatment group,20 cases in control group. Group C has 14 cases in treatment group,10 cases in control group.The results showed that:In safety indicators,72 cases witn Completed observation did not find impairment indicator of liver and kidney function.In efficacy indicators,six groups have a reduced physical phlegm score.Among them,the efficacy of interventions Combined No.l formula and lifestyle is more obvious than lifestyle intervention (P<0.05).In the treatment group of Group A, IAI, apoA, apoB,apoB/apoA,body weight,BMI,hip circumferences significantly reduced (P<0.05).But FINS, IR significantly increased (P<0.05).In the control grou-p of Group A,IAI,waist circumference,WHR significantly decreased (P<0.05);FPG、IR significantly increased (P<0.05).In the treatment group of Group B, fasting blood gluco-se, apoA,apoB,waist,WHR significantly reduced; glycosylated hemoglobin increased slig htly(P<0.05).In the control group of Group B,fasting insulin,insulin resistance index,apo B,waist and hip circumferences decreased,glycosylated hemoglobin was significantly hig her (P<0.05).In the treatment group of Group C, fasting glucose, insulin resistance, wai st and hip circumference was significantly lower;insulin sensitivity index increased signi ficantly (.P<0.05).In the control group of Group C, Fasting insulin, IR, apoB,weight, waist circumference decreased significantly; IAI increased significantly(P<0.05).Conclusion:This study confirmed the safety and efficacy of NO.1,NO.2,NO.1+2 for-mula.NO.1,NO.2,NO.1+2 formula reduced the score of Phlegm dampness constitution, body weight, BMI, waist circumference, WHR, etc. In the period of normal fasting blo od glucose, NO.1 formula tend to reduce apoA,apoB,apoB/apoA. In the fasting glucose undamaged stage of phlegm physical, adjust apolipoprotein will reduce the risk of im paired fasting glucose. In the period of impaired fasting glucose,NO.2 formula tend to reduce fasting blood glucose, apoA,apoB and apoB/apoA.NO.1+2 formula tend to reduc-e fasting blood glucose,IR,and increase IAI.We hold that on the improvement of insuli-n function (insulin resistance index, insulin sensitivity index),No.1+2 formula is more obvious than others. And the comprehensive treatment based on combination Bianti wit-h Bianbing is obvious than the treatment based on Bianbing. So we put forward that interfere with impaired fasting glucose from the angle of conditioning phlegm-dampness constitution to prevent diabetes.Conditioning Phlegm-dampness constitution can prevent the occurrence and reduce the progression of IFG. It advances an earlier pathological stage to intervent prediabetes based on the identification of TCM constitution, and its enforceability is good. This idea is in accord with the conception of treating before dis-ease of TCM.