Effect Of Acupuncture At Feishu And Lingtai Acupuncture Combined With Anticancer Drug Paclitaxel On Expression Of CYP3A And P - GP Protein In Lung Cancer Mice

Purpose：Toobservetheacupunctureshenshupointofthelungtonewanti-cancerdrug paclitaxel distribution trend in pulmonary squamous cell carcinoma of themice and the effect of chemotherapy drugs targeted to medicine research providesa new train of thought, further verify the needle medicine and the mechanismof synergy.Material and method：Select36lung squamous cell carcinoma of the mice,with the method of random, divided into9groups, namely model group, acupuncturelung yu group, the taxol drug group, the combination of acupuncture with medicinegroup (acupuncture lung yu+taxol drug group), each group of six. Acupunctureneedle, medicine, and the combination of acupuncture with medicine group, withcupping therapy, once a day, five days in a row. Paclitaxel in abdominal cavityinjection dosage, the last time immediately after acupuncture. Afterdosing,2,8,12,241h each time point6only lung and liver tissue in mice. Usingthe ELISA method for each viscera P glycoprotein expression analysis.Results：Acupuncture,paclitaxel,acupuncturecombinedpaclitaxelcaninhibittumor growth, tumor suppression has a good effect. Needle thorn combinedpaclitaxel tumor suppression effect is more significant.Conclusion：CYP3A enzyme activity in the liver, according to the results of taxol drug group,acupuncture Feishu+drug taxol, Lingtai+drug taxol acupuncture group,acupuncture Feishu+Lingtai+paclitaxel CYP3A enzyme activity in drug groupand the blank group, model control group, acupuncture Feishu group, theacupuncture Lingtai group, acupuncture Feishu+Lingtai group have significantdifference, the difference was statistically significant (p <0.05), enzyme activity increased, but the needle Feishu+taxol drug group, acupuncture Lingtai+drug taxol, needle Feishu+Lingtai+taxol drug group and drug taxol comparisonof enzyme activity inhibition, slightly but there was no statisticallysignificant difference (p>0.05). acupuncture of taxol in the distribution oflung cancer in mice has the tendency of influence, have a targeted effect;"Feishu " and"Lingtai" tendency of effect of drugs in the lungs is effective," Feishu " to drugs in lungs of the tendency of superior to the "Lingtai"; Showsthat combination of acupuncture with medicine promote drug targetingdistribution have synergy, which may be acupuncture combined to enhance theantitumor mechanism of taxol. Acupuncture in combination with paclitaxel caninhibit P-GP, CYP3A4protein expression,the action of CYP3A4enzyme activity,synergies. For needle medicine and treatment of lung cancer has importantscientific significance and potential clinical application prospect, for the"needle medicine simultaneously, targeted therapy" new experimental basis forlung cancer treatment and treatment.