Study On Intervention Effect Of Cognitive Behavioral Therapy In Schizophrenia Patients With High Risk

Schizophrenia has been referred to as the worst disease to affect mankind and, according to the World Health Organization(WHO), it is among the most burdensome of illnesses. In addition to the morbidity associated with the illness for individuals and the burden for families and society, the life expectancy of patients with schizophrenia is 15–20 years below that of the general population. In addition to the direct costs of care, the indirect costs due to loss of productivity, psycho social problems, and burden on caregivers make schizophrenia a uniquely costly illness. The relatively long hippodrome in schizophrenia allows for indicated prevention as an effective intervention. “High-risk” individuals have subtle symptoms and,without intervention, a third would develop psychosis within 1 year, and many will have poor functional outcomes, even in the absence of psychosis. So,intervention for “High-risk” individuals seems very important.Objective To evaluate the efficacy of cognitive behavioral therapy on ultra-high-risk for psychosis.Methods 27 ultra-high-risk for psychosis were randomly divided into CBT group and control group. The treatment group received cognitive behavioral therapy treatment,the control group,only received the general health and physical education.PANSS and SDSS were used to assess the two group at ore-therapy and 6 、12、18、and 24 weeks after intervention.MCCB were used to assess the two group at ore-therapy and6、12、18、24 weeks after intervention.Result 1、After12 weeks treatment,the study group PANSS total score and positive factor score decreased,lower than the control group( P < 0.05). 2、After12 weeks treatment,the study group PANSS total score and positive factor score decreased,lower than Before the treatment( P < 0.05). 3 、 PANSS negative factor score was no significant difference between two groups(P>0.05). 4、SDSS score were no significant difference between two groups(P>0.05). 5、After24 weeks treatment,the scores of symbol coding, simple visual memory test-revised edition( BVMT-R),continuous performance test( CPT) among the 2 groups were significant difference( all P < 0. 05). 6、After 18 weeks treatment,the scores of continuous performance test( CPT) wassignificant difference than before the treatment(P < 0. 05). After 24 weeks treatment,the scores of continuous performance test( CPT),symbol coding, simple visual memory test-revised edition( BVMT-R) well significant difference than before the treatment(P < 0. 05).Conclusion 1.The cognitive behavioral therapy could enhance the level of positive symptom in ultra-high-risk for psychosis.The cognitive behavioral therapy could not enhance the level of negative symptom in ultra-high-risk for psychosis. 2.The cognitive behavioral therapy could not enhance the level of social function in ultra-high-risk for psychosis. 3.The cognitive behavioral therapy could enhance the level of cognitive impairment in ultra-high-risk for psychosis.