Study On Pharmacokinetics Of Florfenicol In European Eel (Anguilla Anguilla)

Florfenicol is one of the antibiotics widely used in aquaculture. In this study, the pharmacokinetic and residual characteristics of Florfenicol in healthy European eel were studied by using the Reversed Phase High Performance Liquid Chromatography.After the oral administration of Florfenicol by single-dose with 100mg·kg^-1, the metabolism course of Florfenicol in plasma, muscle and liver was accorded with Two-compartment open model. Its theoretical concentration-time equation was as follows: C=23.25e^-0.19t+3.33e^-0.02t+24.67e^-1.14t, C=148.09e^-0.32t+8.05e^-0.02t+169.29e^-0.64t, C=29.58e^-0.31t+2.21e^-0.004t+18.80e^-0.94t.The metabolism course of Florfenicol in kidney was accorded with One-compartment open model. Its theoretical concentration-time equation was as follows :C=404.53(e^-0.11t-e^-0.12t) . After the injection of Florfenicol by single-dose with 100mg·kg^-1, the metabolism course of Florfenicol in plasma was accorded with One-compartment open model, Its theoretical concentration-time equation was as follows: C=220.60 (e^-0.09t-e^-0.11t) .After oral administration , the peak times in plasma, muscle, liver, kidney were 1.98±1.37h, 3.32±0.55h, 0.15±0.33h, 0.64+1.10h respectively. The peak concentration was 14.39 ± 8.39μg·ml^-1, 17.04 ± 2.42μ g·ml^-1, 15.96±2.06μg·ml^-1, 21.03 ±7.12μg·ml^-1 respectively, then the concentration gradually declined. Their concentrations were 4.59 ± 7.65 μg·ml^-1, 0.75 ± 1.10μg·ml^-1, 0.97 ± 0.84μg·ml^-1 in plasma, muscle, kidney respectively 2 days later, but liver could not be detectable. The concentration was 0.11±0.24μg·ml^-1 in plasma 3 days later. At the same time,...