Isolation And Characterization Of Porcine Adenovirus

Adenovirus vector is an earlier and maturer genetic carrier in the respect of gene therapy and genetic immunization after retroviral vector. Comparing with retroviral vector, Adenovirus vector can highly performance to transfer foreign gene into target cell and tissue.As eukaryocyte gene transfer vector, Adenovirus vector has many good quality, such as convenient preparation, wide host range, strong transmissibility, large capacity of wrapping, high tite of virus propagation ,good safe et al. The precedent for using nonhuman Ad as expression vectors primarily came from their no or low pathogenicity for their natural hosts and similarity of their structural and genomic organization with that of HAd5 in the case of the Mastadenovirus species. Var ious nonhuman Ad that are currently under investigation as gene expression vectors include bovine Ad serotype 3 (BAd3), canine Ad serotype 2 (CAd2), chimpanzee Ad serotype 1 (for example; simian adenovirus serotype 25, SAd25), ovine Ad seortype 7 (OAd7), porcine Ad serotypes 3 and 5 (PAd3, PAd5) and fowl Ad serotype 1,8, 9 and 10 (FAd1, 8, 9, 10). Absence of virus...