Study On Intoxication Of Joint Use Of Polyether Ionophore Antibiotics And Tiamulin On Chicks

Maduramicin and Heinanmycin are commonly used Anti-coccidiosis addition agents and Tiamulin is the best drug for the prevention and cure of respiratory diseases.Polyether ionophore antibiotics and Tiamulin are regularly used in combination because of the concurrence of chicken coccidiosis and respiratory diseases. But the intoxication caused by it caused a great loss to poultry industry.Although the intoxications were reported commonly,the systematic observation and study of it's particular pathological changes and pathogenesis were deficiency.This trial is designed to approach the toxic dose, clinical symptoms, pathological changes and pathogenesis caused by it. A drug intoxication model of chicken was created in which Maduramicin or Heinanmycin was used in combination with Tiamulin per os in different doses.The intoxication, visible process and histopathological changes were observed.The variance of the content of K,Zn,Cu in serum and the antibody level of ND serum was checked and analysed dynamicly in order to approach the clinical symptoms,pathological changes and pathogenesis of the intoxication caused by using different types and doses of Polyether ionophore antibiotics and Tiamulin in combination.The experimental result showed that:using recommended dose of Maduramicin and Tiamulin in combination will not cause intoxication and apparent injuries.But serious intoxication of the organism will manifest when redoubled dose of Maduramicin and normal dose of Tiamulin were used in combination,causing versatile pathological changes.Clinical symptoms are growth retardation, dyskinesias, paralysis,etc.. Visible processes are atrophies on Bursa of Fabricius,chests,spleens and immune organs;severe lymphocyte loss on thymus,Bursa of Fabricius,spleens and cecal tonsils; hydropericardium; catarrhal inflammation on glandular stomach and duodenum; degenerate tumescence on heart,liver and kidney. Microscopic examination changes are apparent denaturations on parenchymal organs as liver,kidney,skin and skeletal muscle,;step-up content of K,Zn,Cu in blood and ND antibody level reduction. Recommended dose of Tiamulin and Heinanmycin used in combination will not cause any intoxication too.But when redoubled, Heinanmycin toxicity is enhanced obviously,causing affinis intoxication.This trial states that high dose of Maduramicin or Heinanmycin can cause toxic reaction when used in combination with Tiamulin.