The Nitric Oxide Effect Of Fetus And Placenta Development And Delivery Performance In Mice Late Pregnancy

NO is a important bioactivator to sustain normal structure and function of the uterus,fetus and placenta during the pregnancy. It directly affect the cardiovascular system, enhance the hemangiectasis and regulate the blood supplement of the tissues and organs. NO defect is a important factor of pregnancy-induced hypertension syndrome (PIH) and intrauterine growth restriction(IUGR).In this research, we want to explore the NO's affect on fetus growing development and farrowing rates.we fed the superovulation pregnant mouse (12-20days) and normally mated mouse with L-arginine(500 mg/kg/d) and N(superscriptω)-nitro-L-arginine methyl ester (L-NAME),then we observe the growing development condition and the structure and function change of the uterus,fetus and placenta.L-NAME affects the blood supply and material transportation of uterus,fetus and placenta,inducing the weight loss of the fetus, intrauterine growth restriction, decreasing of live litter percentage and the total weight of uterus and fetus as a percentage of parent weight. The synthesis of NO from placenta has also decreased and the structure impaired. L-arginine has little affect on fetus weight and placenta diameter,but it can extend the length of the fetus,raise the live litter percentage of the superovulation pregnant mouse and increase the weight of intrauterine fetus, improve the blood circulation condition of intrauterine fetus. Besides, L-argirine can rescue the L-NAME impairment to the pregnancy to some extent.Suppression of the NO synthesis will has a strong impact on fetus development and the function of the placenta. L-arginine has no obvious effect on the pregnant mouse,but it can treat the NO synthesis disorder and increase the reproductive efficiency of high yield animal.