The Therapeutic Effects Of Nitric Oxide Donor-Nitroglycerin On Pregnancy Induced Hypertension

Purpose: To evaluate the effects and possibility of Ng in treatment on PIH. Methods: They were divided into four groups: â…  Normal pregnancy(n=11); â…¡ PIH treated only with magnesium sulfate(Mg) (n=11); â…¢ PIH treated only with Ng (n=11) ; â…£ PIH treated with Mg+Ng (n=12). The endothelial nitric oxide synthase (eNOS) in placenta was investigated immunohistochemically and quantitatively, Data such as hernorrheology with high and low stress shear,fibrinogen (Fn) with amine sulfate sedimentation, erythrocyte sedimentation ratio (ESR) in Wintrobe, hemocrit (Hct),platelet aggregation (PAg),concentration of nitrite /nitrate(NO2-/NO3-) in mother and neonatal umbilical serum with nitro-reductase,umbilical artery of ratio of S/D and resistance index(RI) with color Doppler and the effect on PIH groups of decrement of blood pressure were evaluated. Results: In comparison with group â… , 1. the quantity of eNOS in placenta was significantly lower(P<0.01) in group PIH, but no difference among 3 PIH groups. 2. umbilical artery S/D ratio and R1:13 PIH cases were lower significantly after introvascular drip of Ng than before respcctively(pO.O5). 4. PAg: group â…¢ and â…£ decreased significantly after treatment than before (pO.OS). 5. nitrite/nitrate(NOy/N031: each group was lower in umbilical vein serum than in mother serum of antepartum; but compared group PIH with group â… , the difference between umbilical veins was smaller than that between mother veins of antepartum. group â…¢ and â…£ increased significantly after treatment than before (pO.O5); 6.the effect on PIH groups of decrement of blood pressure: compared with group â…¡,blood pressure decreased significantly in group â…¢ â…£(p