| objective To evaluate MRI diagnosis of bone marrow in acute leukemia by observing MRI appearance and calculating T1 value, CNR (ratio of contrastlnoise) in patients before and after chemothrapy, contrasting to materials in clinic and pathology. Materials and methods Thirty-eight patients with acute leukemia served as group before chemothrapy were performed MR examination. Their age 4 to 65 years(mean 18±15), including 19 males and 19 female, 27 acute lymphocytic leukemia (ALL) and 11 acute myelocytic leukemia (AML). Twenty-five patients served as acute leukemia remission group were performed MR examination in relation to treatment with chemotherapy. Nine of 15 patients were monitored more than twice. As control group, 35 healthy volunteers were performed MR examination with identical methods. A 0.5T whole body magnetic resonance scanner was used. A sagittal slice in lumbar spine and a coronal slice in iliac and femur approaching was selected. Spin echo were applied with TRITE 45 0/20 and 700/20 in T1WI, TR/TE 3600/80 in T2WI. Slice thick 5 mm, gap 1 mm., matrix size 180×256 were selected. Serial MR. studies include observation of MRI appearance (study naturally) and measurement of T1 value and CNR (study quantitatively) in all patients. The Clinical and pathological feature connect to MR finding in acute leukemia were found 6 by analyzed and compared with them. Result MIRI appearance of normal control group in T1WI was isointense signal or some mottling of hyperintense signals mixed in the background of isointense signal in marrow of lumbar spine, iliac, and femur approaching. Isointense signal appearance in T2WI was found in all 35 cases of control group in marrow of lumbar spine, iliac, and femur approaching. All 38 cases of acute leukemia at the time of diagnosis compare with control group: hypointense signal in T1WI was found in lumbosacral vertebral, iliac, and femur approaching. But mottling of hyperintense signal was found around acetabulum in 3 of 38 cases, in femoral head and greater trochanter in 8 of 38 cases. Hypointense signal by well-distribute were found in the other cases. Isointense signal in T2WI was found in all 38 cases of acute leukemia at the time of diagnosis. The signal intensity in T1WI tended to normal in all 25 remission cases of acute leukemia. The signal intensity in T1WI in 21 complete remission cases is higher than that in 4 part remission cases. Isointense signal was also found in T2 WI in remission group. Nine cases were monitored after chemotherapy. Isointense signal in T1WI appeared in Six of 9 cases who kept complete remission, but patch appearance of hyperintense signal in T2WI was found in 5 cases (5/6) at the first examination (within 5 days after chemotherapy), and isointense signal at the second examination (2? weeks after chemotherapy). The change of signal intensity in different 7 part of marrow we performed accorded in all 38 cases. The difference of T1 value in lumber, CNR in lumber/subcutaneous fat and femur/subcutaneous fat, B% in blood and marrow were significant between groups of diagnosis and control, diagnosis and remission (PO.05). A significant correlation was seen between T1 value in lumber and B% (B% stand for percentage...
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