The Clinical And Experimental Research On Quantitative Diagnosis Of Pericardial Effusion

Normal volumes of liquid in the pericardiac cavity range from 20 to 50 ml. As much more liquids produced which may even lead to pericardial tamponade, then hydropericardium comes true. Precise judgement of Pericardiac effusion volume (PEV) and its increasing rate should be important to help the clinical diagnosis and timely treatment. So the quantitative diagnosis of the hydropericardium are of great significance. But no inspiring methods and formula were summed up. In our clinical researchs, we found that PEV can be estimated with the help of the echocardiography and PEV were estimated based on section features of the heart measurements: the anterior aspect of the right ventricle wall (R), posterior aspect of the left ventricle wall (L) and the cardiac apex region (A). Purpose: To testify the relationship between R, L, A and the PEV according to the clinical and animal experiment, then deduce the formula to estimate the PEV. Methods: 1) Clinical research: Clinical datas of 48 patients suffered from Pericardiac effusion were collected and analyzed in the following three directions. 1. Quantitative diagnosis of PEV with the combination of echocardiographic and percutaneous catheter-basic pericardial drainage. 2. Treatment of acute purulent hydropericardium with catheter-basic pericardial drainage. 3. The study on the relationships between the increasing rate of PEV with pathogeny and prognosis. 2) Animal research: Fifteen dogs? hydropericardium-models were built up to investigate the relationships between the PEV and the echocardiography of the R, L, A, intropericardial pressure, heart funtion, respiration, heart rate. Results, 1) Clinical research: 1. The results indicate the significant correlation between R, L, (R+L+A ) /3 and the PEV, suit the positive linear regression correlation. But no similar result was found between ?A?and PEV. PEV in area was found to be the thickest place. 2. The clinical observation showed that 5 out of 6 patients suffered from acute purulent pericardial effusion recovered after intropericardia drainage and lavage. 3. As different pathogeny which lead to pericardiac effusion, the increasing rate of PEV and prognosis differed from each other. PEV caused by lung cancer raised most quickly . 4. The relationships between the increasing rate of the PEV and prognosis. All patients suffered from PEV caused by lung cancer died in two years. Only 1 out of 6 hydropericardium patients suffered from uremigenic has been dead. Hydropericardium was not happened again and no other death was reported in other cases. 2) Animal research : 1. The results indicate the significant correlation of linear regression between R, L, (R+L+A )/3 and the PEV, suit the positive linear regression correlation except A. PEV in 揂?area was found to be the thickest place. 2. The intropericardial pressure and PEV were approved to suit positive linear regression correlation. 3. Negative linear correlation was discovered between the rate of flow propagation and PEV. 4. There was no relationship between EF and PEV. 5. Negative logrithmic correlation was detected between the PEV and HR(heart rate). 6. RR (respiratory rate) was found to be 搒quare?related to PEV. Conclusions: 1. The clinical and animal research reveal that the PEV was closely related to the (R+L+A) /3. With the calculation of (R+L+A) /3, the PEV can be estimated according to the linear regression fomula. 2. PEV in area was the thickest place, so area was the most...