The Efficacy Of Shengmai Injection On Hemodynamics And Vasoactive Peptides

Shengmai injection is an extracted herb solution based on the famous recipe of "Shengmai san" which has been widely used in heart dysfunction, angina pectoris, hypotension and shock More reseaches only showed that Shengmai injection could improve the hemodynamics of patients with heart dysfunction after a short - term therapy But it is not sure the direct effect of Shengmai injection on the hemodynamics changes, the relationship between the treatment and vasoactive peptides, and the mechanism about the regulation to blood pressure levelMethods:Part one of the paper, 16 healthy dogs were randomly allocated to two groups after heart failure induced by 2% pentobarbital venous drop One group (10 dogs) received 10ml of Shengmai injection in 100ml infused into the right atrial through Swan - Ganz catheter in 120mm The other group (control) received the same volum of saline Hemodynamic variables and heart function were continuously monitored And vasoactive peptides concentration were measured; 30 patients with heart dysfunction who were administered with Shengmai injection( 50ml) participated in the research the hemodynamics changes of the patients were continuously monitored by noninvasive heart function monitoring system Part two of the paper, 10 anesthesia dogs were received 5 50m1 of Shengmai injection Cardiac output and blood pressure were continuously monitored; 11 patients with hypertension who were administered 10ml of Shengmai injection in 5mm were investigated in this part, and-4-Z~ki~d~f~ - ~hemodynamics were monitored like beforeResults. â‘  Cardiac output of heart failure dogs started to increase in 5 mm after Shengmai injection administered, and it was significantly higher than that of the basic level in 60min( P< 0 05) SPAP, DPAP, PGWP, TPVR and TPR were decreased in 5min as well The significant changes occurred in 60mm after Injection â‘¡ CO of patients with heart failure markedly increased in 30mm, and kept the high level till 120mm STR and PCWP were decreased, and oxygen myocardial consumption had no significant change â‘¢ ANF, ET, TNF kept high concentration in heart failure dogs But they all decreased in 60mm after treatment â‘£ the anesthesia dogs' blood pressure decreased in 5mm after rapid injecting the drug And the different doses of drug resultde in different changesConclusions, â‘  Heart function could be improved by Shengmai injection in 2 hours due to myocardial constriction and cardiac output increased, myocardial oxygen consumption reduced , pre and post - load decreased;â‘¡The blood pressure could be decreased immediately after rapid injection associated with vascular dilated And perhaps the relationship of dose - effect and time - effect may be present;â‘¢ During the therapy, the blood level of ANF, ET, the ratio of ET and CGRP, and TNF were reduced compared with the control...