The Relationship Between MDR1 And MRP Gene And The Mechanism Of Bladder Cancer Drug-resistant And The Clinical Study Of Individual Chemotherapy Of Bladder Cancer

The expression of MDRL and MRP in 48 wax specimens, including 32 patients of primary bladder transitonal cell carcinoma and 16 case of recurrent bladder cancer , who accepted surgery in this hospital were studied using immuno-cbemical method. We analysed the relationship of drug-resistant mechanism and the malignant behavior of the bladder transitional cell carcinoma , such as stage , grade and recurrent from molecular level Then the primary cell culture and the drug sensitive test were done to study how to conquer the drug-resistant of bladder caner, design the rational program from clinical view . The result are as follows: 1: The positive expression of MDR1 in primary and recurrent bladder transitonal cell carcinoma group were 47% and 68.7% . There are statistical significance between primary and recurrent group (P