Study On The X-ray Developable Microspheres

The interventional neuroradiology is a subject that aimed at diagnosis and therapy of some diseases of neural system under the surveiI lance of X~ray. The development of this technology made the therapy of certain diseases that used to be dangerous and difficult easier. The development and application of this technology is tightly related with 1 he manufacture and exploitation of embolism material. Nowadays, there are many embolism materials applied in clinic, they could be classified into two types: solid materials and liquid materials. Currently the widely used liquid embolism materials include silicone, IBCA, HEMA, NBCA, grain alcohol, etc.Objective: This study is to manufacture some kinds of solid embolism materials that could develop under the X-ray. By using these embolism for embolization, the handlers could know many details about the operation at real time, thus to make right decisions during the operation.Methods: The materials we used for producing embolism are gelatin and polyvinyl alcohol (PVA). The contrast mediums being used here arc sulfate barium, diatrizoate, tantalum powder, etc. They are commixed into microspheres by physical and chemical method. The study contains 3 parts. Part 1: produce gelatin and polyvinyl alcohol microspheres by the method ol' emulsificat ion, then evaluate their physical and chemical characteristic. Part 2: embed contrast mediums into gelatin and polyvinyl alcohol microspheres respectively. Part \\: direct embol i /at ion ol' the carotid ol' rabbits with the microspheres that produced anteriorly, and put the tissues under pathological observing after 1,2 and 4 weeks respectively.Results: The gelatin and polyvinyl alcohol microspheres that contain X-ray contrast mediums of one kind or two are visible under X-ray in rabbit's skull. And the handlers could know many details about the embolization in real time.Conclusion: The gelatin and polyvinyl alcohol microspheres that produced by the method of emulsificat ion have appropriate dispersibi1ity, expanding coefficient and specific gravity. Commix contrast mediums such as diatrizoate, sulfate barium into the raw material could make the microspheres be visible under X-ray. Thus, the handler could be ware of more details about the emhol i /.a I ion at real time.