Study On The Relationship Between Central Related Peptides Of Chronic Restrained-stress In Rats And Normal Of Flow Qi Governed By The Liver

The research about the mechanism of stress induced chronical stress as well as its prevetion,elimation has been attracting many scholars for a long time. This project (No. 30000216) was supported by National Natural Science Foundation Committee of China. The following works have been done: Part 1 Theoretical studyA lot of works have been done in eliminating stress of TCM.The liver function includes the physiology and psychology corresponding to stress. CD The liver is in change of regulation the activity of Qi corresponding to the emotion.㏕he livers stores blood, serving as a reservior of blood to regulate the circulating blood volume, which is one important originate of energy. CD The liver stores mood, related to psychology activity.?The liver govens normal flow of Qi, related to the protective mechanism. CD The liver concerns with the endocrinal function.As combination with the viewpoint "the liver govens normal flow of Qi" , the paper expounded the prominent position of the liver from five aspects.l.The concept of stress and stressor : stress is a neurnal-endocrinal reaction caused by intense factor (stressor). Stress is changes of all sorts of function and metabolization caused by some intense stressors (intense factors).2.Pathogenesis of stressQi and blood is important to our body. If the liver functions are properly in this respect, the normal function of Qi as well as blood, free flow of channels, and the proper function of Zang-Fu organs and other structures will ersue as a result. Conversely, dysfunction of the liver may manifest itself by two kinds of morbid conditions, hyperactivity and hypoactivity.Chronic restrained stress is an external stimulation closed to human being. In TCM theory, the knowledge of the mechanism and stress-reaction is subjected to the changing of Qi. The dysfunction of Qi and Zang-organ is one of main courses. The liver is thecenter of the regulation of Qi and blood. 3. The relation between liver and stressAll sorts of circumstances and psychological factors caused the dysfunction of the regulation of Qi, disorder of Yin and Yang. The liver adjusts emotional activities. in medical works regulating and balancing movement of Qi.Yuan dynasty ancient medical scholar had realized the influence of many sorts of harmful stressors. All the time they thought highly of the stressor such as the influence of emotions, kinds of environments factors and psyological factors dysfunction of Qi caused lasting or violence stimulation .The is related to the regulation of emotion based on the function. Ancient medical scholars paid more attention to regulate Qi. Zhudanxi thought that stagnation is the origin of disease. Depression is the root of dispersing depression. Regulating the flow of Qi is the emphasis of TCM. And later, many medical scholars took relieving stagnation as the root of treatment.4. The relationship between the liver and stress: as well as neural-endocrine-immune network (NEIN) from the concept of theory of stress, homestasis regulation, and the liver. The author concludes that the disorder of NEIN in stress should impute to the abnormal of liver Qi.5. Therapeutic method for stressIn TCM theory, the mechanism of stress is the disorder of Qi.The pathological changes of Qi and blood, like that of the properity and decline of vital Qi and pathogens of the imbalance of Yin and Yang, is not only the foundation of various pathological of ZangFu organs, channels, but also the basis for analysing and studying the pathogenesis of various diseases .In recent years, it showed that physiological function and pathological changes are involved many systems included neural, endorphine, immunity, digest, and cardio-diseases by liver essence research. In the theory of Zang-organ of TCM, the function of liver is included physiology and psychology fields. They are connected with stress. It has practical significance to prevent and eliminate harmful stress reaction in the field of discussion of stress in TCM.Part 2 Experiental studyStress is a course of ad...