Antibody To Sulfatide And P2 Myelin Protein And Ganglioside GM1 In Guillain-Barré Syndrome And Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Objective: To investigate the clinical significance of Antibody to Sulfatide and P2 myelin protein and Ganglioside GM1 in Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: The serum levels of Antibody to Sulfatide and P2 myelin protein and Ganglioside GMlwere detected by enzyme linked immunosorbent assay(ELISA) in 30 GBS patients , 24 CIDP patients , 24 other peripheral neurpathy (OPN) patients, 22 motor neuron disease (MND) patients, 22 other neurological (OND) patients and 50 normal controls(NC). GBS patients and CIDP patients was divided into subtype according to clinic features and electrophysiological and morphological data. Result: (1) Compare to patients with other neurological disease and nomal control group, the positive rate of the sulfatide antibodies and P2 antibodies and IgM-GMl antibodies in CSF were much higer in GBS group(P<0.05). (2) Compare to patients with other neurological disease and nomal control group, the positive rate of the sulfatideantibodies and P2 antibodies in CSF were much higer in CIDP group(P<0.05,P<0.01) .(3) High anti-sulfatide levels in CSF most frequently correlated with an sensory axonal neuropathy . High anti-Pi levels in CSF may not be an responsible antibodies in GBS and CIDP.High anti-GMl levels in CSF most frequently correlated with an motor neuropathy .(4)The level of antibodies have no relation with the severity of the disease. (5) The level of antibodies have no relation between the serum and the CSF . The level of antibodies in CSF have no relation with the level of protein in CSF. Conclusion: Our results indicate that detection of sulfatide antibodies in CSF may be useful in the clinical diagnosis of axonal sensory neuropathy and that detection of GM1 antibodies in CSF may be useful in the clinical diagnosis of motor neuropathy. Our studies demonstrate that the antibodies to P2 may not be an responsible antibodies in GBS and CIDP but that may have relation to repairing of disease.