| Objective Thymus is the body's immunity central apparatus, it has important effect on T cell's growth, polarization and maturation. The thymus hormone that the thymus excretes can contradict tumor, virus and bacteria, it can also improve the body's cell immunity, non-special immunity and combating infection ability through promoting cell's function and quantity. Along with the age goes up, thymus gradually shrank, the thymus hormone's level gradually declined, tumor 's emergence will increase. When the body suffered from malignancy, on the one hand, tumor restrained cell immunity function, antibody's production and the body's immunity effect through inducing restraining T cell, so it accelerated tumor's growth, on the other hand, tumor induced body fluid restrained gene, which prevented T cell and NK cell from killing tumor and restrained lymphocyte to mitotic multiplication reaction, indeed it accelerated tumor's growth. IgG,IgM,IgA are produced by B cell, in the course of B cell's activation, it needs NK cell's assistant. Before thymus transplantation, the patient associated with tumor has fewer TH cell and its function recedes, so B cell's activation was suffocated and the ability of producing Ig was weak. After thymus transplantation, the embryo's thymus has trunk cell that comes from the embryo's yolk bag, embryo liver and marrow, it excretes a great deal of thymus hormone which change lymphocyte into mature T lymphocyte through multiplication and differentiation, then it help to turn B cell into serous cell, the quantity of the serous cell increases, the antibody that it produces also increases, that is the content of IgA, IgM and IgG is increased. This research is mainly to explore the thymus transplantation's effect on immunity function of patient associated with malignant tumor.Methods Thirty-four patients associated with malignant tumor were selected anddivided into two groups randomLy: transplantation group(n=16) and antithesis group (n=14) , the patients of transplantation group were all transplanted uith homogeneity and iiartant embryo's thymus between six to eight months in the elboiu joint, about tiuo or three venous blood were taken out just at this time: before operation, after operation 1,3,6 months respectively, IgA, IgM and IgG were examined. In addition, IgA, IgM and IgG of the patients of antithesis group were also examined at this time: just was in hospitaUafter being in hospital 1,3,6 months respectively. Variables were expressed as mean + standard deviation (x + s) and self-antitheses t tests were done to evaluate differences, p value of less 0. 05 was required for significance.Results In the transplantation group patients, the changes of IgA, IgM and IgG after transplantation 1 month were not significant (P>0. 05), the changes of IgA, IgM and IgG after transplantation 3 and 6 month were significant (P<0. 05), these indexes increased remarkably. In the non-transplantation group patients, the changes of IgA, IgM and IgG after being in hospital 1,3,6 months were not significant (P>0. 05) ?Conclusions In the thymus transplantation patients associated with malignant tumor, the contents of IgA, IgM and IgG increased significantly after transplantation 3 and 6 months. Thymus transplantation can remarkably improve immunity function of patients associated with malignant tumor.
|
PDF Full Text Request