Elementary Study Of Magnetic Resonance Spectroscopy In Rats Of Diffuse Axonal Injury

Diffuse axonal injury-DAI is a kind of severe closed brain injury.lt is characterized by selective damage to white mater tracts that is caused in part by the severe inertial strain created by rational acceleration and deceleration ,which is often associated with motor vehicle accidents.DAI is typically difficult to detect by using conventional imaging techniques because it is microscopic in nature.Now proton magnetic resonance spectroscopy-'H MRS appears to be a useful tool for assessing DAI.It is primary study the association between the changing of NAA and Cho and Cr and pathology changing which is very important to grasp the diagnosis prognosis and effect of therapy in DAI.OBJECT :This study was conducted to determine whether proton magnetic resonance spectroscopy is a sensitive method for detecting diffuse axonal injury.MATERIALS and METHODs: SD rats with DAI (440-460Kg,mean weigth,450Kg)were studied on a 1.5-T system with MR spectroscopy of the splenium. JHMRS was used to calculate the N-acetylaspartate (NAA)/creatine (Cr)ratio and choline(Cho)/Cr ratio and NAA level. Scans was obtained before injury and 4h-48h after injury.RESULTS : Contrasted with normal rats, all the diffuse axonal injuried rats showed diminished NAA/Cr levels in the splenium specially after 4h and 48h. While ratios of Cho/Cr and NAA peak has no statistically significant associations with axonal injury.CONCLUSION :A proton MRS examination may be particularly useful in evaluating diffuse axonal injury.lt is conducted that MRS is a sensitive tool in detecting DAI.